DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment magu and IGFBP5

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_000590.1	Gene:	IGFBP5 / 3488	HGNCID:	5474	Length:	272	Species:	Homo sapiens

Alignment Length:	184	Identity:	46/184 - (25%)
Similarity:	61/184 - (33%)	Gaps:	51/184 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 HTNTIGTGV--NPHSYSEDAS---GSEEHEDNYEDSATGYGGEEDDSQGADLPSSRTHIPSLYML 379
            |....|.||  |..||.|...   .|.||    |:..|....||..|.....| ..|.|..|
Human    91 HALLHGRGVCLNEKSYREQVKIERDSREH----EEPTTSEMAEETYSPKIFRP-KHTRISEL--- 147

  Fly   380 NSKPETASQD-------------LENDSN-----------------CWMDQSVTLEEQGHGGKSV 414
              |.|...:|             .||.::                 |......:|:|.....:.|
Human   148 --KAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMV 210

  Fly   415 ---LFVPQCLPDGRYQRIQCYSS--TSTSYCWCVNEDTGKSIPGTSVKNKRPQC 463
               :::|.|...|.|:|.||..|  .....||||:: .|..:||....:...||
Human   211 PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDK-YGMKLPGMEYVDGDFQC 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052
		TY	88..139	CDD:238114
		SPARC_Ca_bdg	180..274	CDD:287550
		SPARC_EC	<219..281	CDD:238155
		TY	396..463	CDD:238114	19/71 (27%)
IGFBP5	NP_000590.1	IB	25..101	CDD:197525	4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..130		5/22 (23%)
		Thyroglobulin_1	192..263	CDD:395039	19/71 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000