DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment magu and IGFBP3

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001013416.1	Gene:	IGFBP3 / 3486	HGNCID:	5472	Length:	297	Species:	Homo sapiens

Alignment Length:	167	Identity:	43/167 - (25%)
Similarity:	63/167 - (37%)	Gaps:	57/167 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 ASGSEEHEDNYEDSATGYGGEEDDSQGA-DLPS-SRTH---IPSLYMLNSK-------------- 382
            |.|......|..:|      |||.|.|: :.|| |.||   .|..:.|:||
Human   133 APGEPPAPGNASES------EEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQR 191

  Fly   383 ----PETASQDLENDSN----------CWMDQSVTLEE---------QGHGGKSVLFVPQCLPDG 424
                .|:.|.|.:|.|:          |..:...||..         :|      :.:|.|...|
Human   192 YKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRG------VHIPNCDKKG 250

  Fly   425 RYQRIQCYSS--TSTSYCWCVNEDTGKSIPGTSVKNK 459
            .|::.||..|  ....:||||:: .|:.:||.:.|.|
Human   251 FYKKKQCRPSKGRKRGFCWCVDK-YGQPLPGYTTKGK 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052
		TY	88..139	CDD:238114
		SPARC_Ca_bdg	180..274	CDD:287550
		SPARC_EC	<219..281	CDD:238155
		TY	396..463	CDD:238114	20/75 (27%)
IGFBP3	NP_001013416.1	IB	38..115	CDD:197525
IGFBP3	NP_001013416.1	Thyroglobulin_1	219..291	CDD:306570	20/75 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000