DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment magu and Fstl4

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_796033.2	Gene:	Fstl4 / 320027	MGIID:	2443199	Length:	841	Species:	Mus musculus

Alignment Length:	850	Identity:	154/850 - (18%)
Similarity:	236/850 - (27%)	Gaps:	362/850 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ARCVLFVTWLAVFIATGKSDDQLMKLPACAAKQGECDDNEGPVCGTDGQTYPTRCHLLRAQC--G 65
            :||:|..|       ||:        |:|...: .|.....||||:||:.|...|.|.||.|  |
Mouse    73 SRCLLNRT-------TGQ--------PSCQCLE-VCRPRYMPVCGSDGRLYGNHCELRRAACLLG 121

  Fly    66 GHQVSLKYSGSC----NAC---------------------------------------------- 80
            ...||: :|..|    :.|
Mouse   122 KRIVSV-HSKDCFLKGDMCTMAGYARLKNVLLALQSRRQPLPQGTPRQSLASQKRLLVESLFKDL 185

  Fly    81 ----------LEAVKFARRQQERDPGYFVPRC-----------RKDGN------FAAMQ------ 112
                      ||..::..::|:.|..  :.||           ..||:      :.|.|
Mouse   186 DADGNGHLGSLELAQYVLKEQDMDGS--LNRCSPSDLLRFDDYNSDGSLTLGEFYTAFQVIQLSL 248

  Fly   113 --------------------C-----------YGNNGCWCSDSQGRPIAD---DNKQFRRK---- 139
                                |           :..||...|......|.|   |...:..|
Mouse   249 APEDKVSVTTVTVGLSTVLTCAIRGDLRPPIIWKRNGLTLSFLGLEDINDFGEDGSLYITKVTTV 313

  Fly   140 --GKLRCRANRRDRRRLASHQIGYN--------PDTSASKGSSEAGSTAHRTCSKSDRSQFNTNL 194
              |...|.|...: :.:.:|.:..|        |:|.|.:....|....|.......|..:..|.
Mouse   314 HMGNYTCHALGHE-QLVQTHVLQVNVPPVIRVYPETQAQEPGVAASLRCHAEGIPLPRIIWLKNG 377

  Fly   195 MRMFRNEAQSFFRQPSLSDSHILEWQFSKLDTNGNKLLDRQEI----------------RELKKV 243
            |.:....::......:.|:.||...::.  ||.....:.:.|:                :.|..:
Mouse   378 MDVSTQMSKQLSLLANGSELHIGSVRYE--DTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANI 440

  Fly   244 L------------------------------RRNVKPRR---------CGRTFGKYCDVTKDANL 269
            |                              :|.:||..         |.|..|   |.|:..
Mouse   441 LWREEGLSVGNMFYVFAEDGIVVIHPVDCEVQRRLKPTEKIFMSYEEICPRVEG---DATQPC-- 500

  Fly   270 NWLEWS---------VCFTKEFHNRSAVVNLLASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIG 325
               :|:         :...:...||..||::.|...                        ..:||
Mouse   501 ---QWASAVNVRNRYIYVAQPALNRVLVVDVQAQKV------------------------LQSIG 538

  Fly   326 TGVNPHSYSED--------ASGSEEHEDN-----YEDSATGYGGE--EDDSQGAD---LPSSR-- 370
            ....|...|.|        .|..:.|:..     ..:::||.|..  .....|.|   :|.:.
Mouse   539 VDPLPVKLSYDKSHDQVWVLSWGDMHKSQPSLQVITEASTGQGQHLIRTPFAGVDNFFIPPTNLI 603

  Fly   371 -THIPSLYMLN-SKPETASQDLENDSNCWMDQSVTLEEQGHGGKSVLFVPQCLPD-------GRY 426
             .||...::.| :.|.....|||   .....::::|...|           |:|.       |.|
Mouse   604 INHIRFGFIFNKTDPAVHKVDLE---TLMALKTISLRHYG-----------CMPQAMAHTHLGGY 654

  Fly   427 QRIQCYSSTSTSYCWCVNEDTG----------------KSIPGT-----------SVKNKRPQCD 464
            ..:||...|.||        ||                ..|.||           ||.||.|...
Mouse   655 FFVQCQQDTPTS--------TGPQLLIDSVTDSVLGPNSDITGTPHVSPDGRFIVSVSNKGPWLH 711

  Fly   465 -ESVAVRPMKGCTEPRKTQFLKELKAYLNTSLLP---SSTTGSNSSMWKTDDER----IATLSFV 521
             :.|.||        .:.|.|.:||.....|.|.   |.|.||..:.:.|.|:.    ...||..
Mouse   712 VQEVTVR--------GEIQTLYDLKINPGISDLAFQHSFTEGSQYNAYATLDKEPDLLFLELSTG 768

  Fly   522 YLDKNKNKSWDRR----EW----KNFRD-------LVTSA--SHLRRCGKKMPRYCDVNGDKKIS 569
            .:.:.||.....|    .|    :..||       |:|.|  |.....|::....|:|:|.|..:
Mouse   769 KMGRLKNLKEPPRGPAPTWGGPRRVLRDSGLFGQYLLTPAQESLFLVNGRQNALRCEVSGIKGAA 833

  Fly   570 LAEWL 574
            ...|:
Mouse   834 TVVWV 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	17/40 (43%)
		TY	88..139	CDD:238114	15/107 (14%)
		SPARC_Ca_bdg	180..274	CDD:287550	19/148 (13%)
		SPARC_EC	<219..281	CDD:238155	14/125 (11%)
		TY	396..463	CDD:238114	21/100 (21%)
Fstl4	NP_796033.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..54
		KAZAL_FS	92..132	CDD:238052	17/40 (43%)
		EFh	178..242	CDD:298682	9/65 (14%)
		EF-hand_7	178..241	CDD:290234	8/64 (13%)
		IG_like	255..322	CDD:214653	10/66 (15%)
		Ig	266..322	CDD:143165	10/55 (18%)
		I-set	340..429	CDD:254352	14/90 (16%)
		Ig2_Follistatin_like	357..432	CDD:143213	11/76 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910