DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment magu and Tg

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	137/636 - (21%)
Similarity:	214/636 - (33%)	Gaps:	180/636 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PTRCHL--LRAQCGGHQVSLKYSGSCNACLEAVKFARRQQERDPGYFVPRCRKDGNFAAMQCYGN 116
            ||:|.:  ..|...||.                             ::|.|.:||::..:||...
  Rat   299 PTKCEVEQFTATSFGHP-----------------------------YIPSCHRDGHYQTVQCQME 334

  Fly   117 NGCWCSDSQGRPIADDNKQ----FRRKGKLRCRANRRDR-RRLASHQIGY-NPD---TSASKGSS 172
            ..|||.|:||..|....:|    |..|.: .|.:.|:.. .||.....|| :|.   :|..:...
  Rat   335 RMCWCVDAQGIEIPGTRQQGQPLFCAKDQ-SCASERQQALSRLYFETPGYFSPQDLLSSEDRLVP 398

  Fly   173 EAGSTAHRTCSKSDRSQF-NTNLMRMFRNEAQSFFRQPSLSDSHILEWQFSKLDTNGNKLLDRQE 236
            .:|:....:|....:..| ::.|:|....|     |...||:|               :.|.|:.
  Rat   399 VSGARLDISCPPRIKELFVDSGLLRSIAVE-----RYQQLSES---------------RSLLREA 443

  Fly   237 I------RELKKV-LRRNVKPRRC-----GRTFGKYCDVTKDANLNW---LEWSVCFT-KEFHNR 285
            |      |||..: |:....|:|.     |.||     :...|.||.   |.....|. .:|..:
  Rat   444 IRAIFPSRELAGLALQFTTNPKRLQQNLFGGTF-----LVNAAQLNLSGALGTRSTFNFSQFFQQ 503

  Fly   286 SAVVNLLASSAAT-----------APPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASG 339
            ..:...|....||           :.|......:....| ..::....|.|..||
  Rat   504 FGLPGFLVRDRATDLAKLLPVSLDSSPTPVPLRVPEKRV-AMNKSVVGTFGFKVN---------- 557

  Fly   340 SEEHEDNYEDSATGYGGEEDDSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMDQSVTL 404
            .:|::|..:...:          ..:||.   .:..|....|.||..::||.:............
  Rat   558 LQENQDALKFLVS----------LMELPE---FLVFLQRAVSVPEDRARDLGDVMEMVFSAQACK 609

  Fly   405 EEQGHGGKSVLFVPQCLPDGRYQRIQCYSSTSTSYCWCVNEDTGKSIPGTSVKNKRPQCDESVAV 469
            :..|.     .|||.|..:|.|:.||||:..    |||||.. ||.:.|:.|....|:|
  Rat   610 QTSGR-----FFVPSCTAEGSYEDIQCYAGE----CWCVNSQ-GKEVEGSRVSGGHPRC------ 658

  Fly   470 RPMKGCTEPR-KTQFLKELKAYLNTSLLPSSTTGS--------NSSMWKTDDER---IATLSFVY 522
             |.| |.:.| :.|.|...:...::..:|:.|:..        ||..:..|.|.   ..|.|.:.
  Rat   659 -PTK-CEKQRAQMQNLAGAQPAGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIPGTQSTIG 721

  Fly   523 LDKNKNKSWDRREWKNFRDLV------------TSASHLRRC---GKKMPRYCDVNGDKKISLAE 572
            ..|........:..:.|..:|            .|:.::.:|   |:.||..||...::.....|
  Rat   722 EPKLCPSVCQLQAEQAFLGVVGVLLSNSSMVPPISSVYIPQCSTSGQWMPVQCDGPHEQVFEWYE 786

  Fly   573 WLNCLQATPRESATTA----KPAQSNETASPKF------------QGVNPV 607
            ..| .|.:..:..|||    |.....|.||..|            |.:.||
  Rat   787 RWN-TQNSDGQELTTATLLMKLMSYREVASTNFSLFLQSLYDAGQQSIFPV 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	6/24 (25%)
		TY	88..139	CDD:238114	15/54 (28%)
		SPARC_Ca_bdg	180..274	CDD:287550	25/109 (23%)
		SPARC_EC	<219..281	CDD:238155	17/77 (22%)
		TY	396..463	CDD:238114	21/66 (32%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114	18/86 (21%)
		TY	<613..658	CDD:238114	21/54 (39%)
		TY	661..724	CDD:238114	13/63 (21%)
		TY	730..>776	CDD:294100	8/45 (18%)
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768
		COesterase	2198..2719	CDD:278561
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D444674at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920