DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment magu and FSTL4

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_055897.1	Gene:	FSTL4 / 23105	HGNCID:	21389	Length:	842	Species:	Homo sapiens

Alignment Length:	694	Identity:	130/694 - (18%)
Similarity:	226/694 - (32%)	Gaps:	209/694 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ARCVLFVTWLAVFIATGKSDDQLMKLPACAAKQGECDDNEGPVCGTDGQTYPTRCHLLRAQC-GG 66
            :||||          :.|:.:     |.|...:. |..:..||||:||:.|...|.|.||.| .|
Human    74 SRCVL----------SRKTGE-----PECQCLEA-CRPSYVPVCGSDGRFYENHCKLHRAACLLG 122

  Fly    67 HQVSLKYSGSC----NACLEAVKFARRQ-------------QE----RDPGYFVPRCRKDGNFAA 110
            .::::.:|..|    :.|..| .:||.:             ||    :||. ...|...:..|..
Human   123 KRITVIHSKDCFLKGDTCTMA-GYARLKNVLLALQTRLQPLQEGDSRQDPA-SQKRLLVESLFRD 185

  Fly   111 MQCYGNNGCWCSDSQGRPIADDNKQFRRKGKLRCRANRRDRRRLASHQIGYNPDTSAS-KGSSEA 174
            :...||.....|:.....:   .||...:..|.|...  |..|...    ||.|:|.: :....|
Human   186 LDADGNGHLSSSELAQHVL---KKQDLDEDLLGCSPG--DLLRFDD----YNSDSSLTLREFYMA 241

  Fly   175 GSTAHRTCSKSDRSQFNT---NLMRMFRNEAQSFFRQPSLSDSHILEWQFSKLDTNGNKLLDRQE 236
            ......:.:..||....|   .|..:.........|.|.:       |:.:.|..|   .||.::
Human   242 FQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPII-------WKRNGLTLN---FLDLED 296

  Fly   237 IRELKKVLRRNVKPRRCGRTFGKYCDVTKDANLNWLEWSVCFTK------EFH----NRSAVVNL 291
            |.:.             |.....|  :||...::...:: |...      :.|    |...|:.:
Human   297 INDF-------------GEDDSLY--ITKVTTIHMGNYT-CHASGHEQLFQTHVLQVNVPPVIRV 345

  Fly   292 LASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSED-----ASGSEEHEDN--YED 349
            ...|.|..|..:.....|   ..|........:..||:..:....     |:|||.|..:  |||
Human   346 YPESQAQEPGVAASLRCH---AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYED 407

  Fly   350 SATG---------YGGEEDDSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMDQSVTLE 405
              ||         .|.:||             |.||::.:|..:|.:..|      |.::.:::.
Human   408 --TGAYTCIAKNEVGVDED-------------ISSLFIEDSARKTLANIL------WREEGLSVG 451

  Fly   406 EQ----GHGGKSVLFVPQC------LPDGR----YQRIQC--YSSTSTSYC-WCVNEDTGKSIPG 453
            ..    ...|..|:....|      .|..:    |:.| |  ....:|..| |         :..
Human   452 NMFYVFSDDGIIVIHPVDCEIQRHLKPTEKIFMSYEEI-CPQREKNATQPCQW---------VSA 506

  Fly   454 TSVKNK-----RPQCD-------------ESVAVRPMKGCTEPRKTQFLKE------------LK 488
            .:|:|:     :|...             :|:.|.|:     |.|..:.|.            .|
Human   507 VNVRNRYIYVAQPALSRVLVVDIQAQKVLQSIGVDPL-----PAKLSYDKSHDQVWVLSWGDVHK 566

  Fly   489 AYLNTSLLPSSTTGSNSSMWKT-----DDERIAT-------LSFVYLDKNKNKSWDRREWKNFRD 541
            :..:..::..::||.:..:.:|     ||..|..       :.|.::....:.:..:.:.:....
Human   567 SRPSLQVITEASTGQSQHLIRTPFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAVHKVDLETMMP 631

  Fly   542 LVTSASHLRRCGKKMPRYCDVNGDKKISLAEWLNCLQATPRESA 585
            |.|...|...|..:...:..:.|      ..::.|.|.:|..:|
Human   632 LKTIGLHHHGCVPQAMAHTHLGG------YFFIQCRQDSPASAA 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	15/39 (38%)
		TY	88..139	CDD:238114	12/67 (18%)
		SPARC_Ca_bdg	180..274	CDD:287550	16/96 (17%)
		SPARC_EC	<219..281	CDD:238155	11/67 (16%)
		TY	396..463	CDD:238114	14/88 (16%)
FSTL4	NP_055897.1	KAZAL_FS	93..133	CDD:238052	15/39 (38%)
		EFh	180..250	CDD:298682	15/78 (19%)
		IG_like	256..337	CDD:214653	16/106 (15%)
		IGc2	265..326	CDD:197706	13/86 (15%)
		I-set	341..430	CDD:254352	24/106 (23%)
		Ig2_Follistatin_like	358..433	CDD:143213	20/92 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910