DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment magu and AgaP_AGAP005450

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_315453.4	Gene:	AgaP_AGAP005450 / 1276143	VectorBaseID:	AGAP005450	Length:	538	Species:	Anopheles gambiae

Alignment Length:	560	Identity:	105/560 - (18%)
Similarity:	159/560 - (28%)	Gaps:	206/560 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CAAKQG-----ECDDNEGPVCGTDGQTYPTRCHLLRAQC---GGHQVSLKYSGSC---NACLEAV 84
            |...:|     .|...:..||||||:||..|| :||.|.   |...|||.:.|.|   :...|:.
Mosquito    86 CERSKGSPCNHRCPTEKDLVCGTDGRTYLNRC-MLRVQACRVGTAAVSLAHVGPCANGSVIRESC 149

  Fly    85 KFARRQQERDPGYFVPRCRKDGNFAAMQCYGNNGC-----WCSDSQGRPIADDNKQFRRKGKLRC 144
            ........:|.    |.|..|||..      |:.|     .|    |:.:.       |..:..|
Mosquito   150 PVDCNSAPQDG----PVCASDGNVY------NSTCQMKLITC----GQGVV-------RTSRKHC 193

  Fly   145 RANRRDRRRLASHQIGYNPDTSASKGSSEAGSTAHRTCSKSDRSQFNTNLMRMFRNEAQSFFRQP 209
            ::.|..|                    ......|..||....|...:...||. .|..:..|..|
Mosquito   194 QSTRNCR--------------------ESCWRVARPTCGSDGRLYASACKMRA-SNCGKHVFEVP 237

  Fly   210 SLSDSHILEWQFSKLDTNGNKLLDRQEIRELKKVLRRNVKPRRCGRTFGKYCDVTKDANLNWLEW 274
                   :.:..|:....|:......:|.:......::.:...||          .|.|   :..
Mosquito   238 -------ISYCMSQERAGGSSHSASNKIEDCPTECPKDAQQMICG----------SDGN---IYT 282

  Fly   275 SVCFTKEFHNRSAVVNLLASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASG 339
            |:|..|..                             |.....:....|:.......:..:....
Mosquito   283 SMCELKML-----------------------------NCGQKKKIQALTLDRCKQKMNRCKSLPA 318

  Fly   340 SEEHEDNYEDSATGYGGEEDDSQGADLPSSRT-------------------HIPSLYMLNSKPET 385
            .::|..|   .||.:|.::|...|.|   |:|                   ||.....|.||
Mosquito   319 CKQHSKN---GATFFGDQKDMLCGTD---SKTYNNECELARATCLRGVQLAHIGPCTQLKSK--- 374

  Fly   386 ASQDLENDSNCWMDQSVTLEEQGHGGKSVLFVPQCLPDGRYQRIQCYSSTSTSYCWCVNEDTGKS 450
              .|:.:.|:|..|:    |:.|         |.|..||...:.:|.....|    |     |..
Mosquito   375 --VDVTDCSSCTYDE----EQTG---------PICGSDGNTYKSRCEMKQKT----C-----GLR 415

  Fly   451 IPGTSVKN---------------------------------KRPQCDESVAVRPM---------K 473
            :...|:||                                 :|..|...:.:.||         |
Mosquito   416 VVPVSLKNCATTALCEANCEQQPTNYVCGSDNKLYPNECHMRRENCGRHMFLVPMKRCLAAFSFK 480

  Fly   474 GCTEPRKTQFL----KELKAYLNTSLLPSSTTGSNSSMWK 509
            ||::....:|.    .:.|.|.|...|......|.|.:.|
Mosquito   481 GCSKICPQEFEPVCGTDGKTYSNECFLSIENCRSRSMVQK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	19/41 (46%)
		TY	88..139	CDD:238114	10/55 (18%)
		SPARC_Ca_bdg	180..274	CDD:287550	15/93 (16%)
		SPARC_EC	<219..281	CDD:238155	9/61 (15%)
		TY	396..463	CDD:238114	16/99 (16%)
AgaP_AGAP005450	XP_315453.4	KAZAL_FS	37..>73	CDD:294071
		KAZAL	94..139	CDD:197624	19/45 (42%)
		KAZAL_FS	198..>232	CDD:294071	8/54 (15%)
		KAZAL	260..306	CDD:197624	9/87 (10%)
		KAZAL_FS	<335..368	CDD:294071	7/35 (20%)
		KAZAL_FS	430..>461	CDD:294071	1/30 (3%)
		KAZAL	482..526	CDD:197624	9/39 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910