DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment magu and smoc1

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_012823493.1	Gene:	smoc1 / 100145733	XenbaseID:	XB-GENE-989094	Length:	491	Species:	Xenopus tropicalis

Alignment Length:	666	Identity:	147/666 - (22%)
Similarity:	232/666 - (34%)	Gaps:	241/666 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLARCV-LFVTWLAVFIATGKSDDQLMKLPACAAKQG--------------ECDDN-----EGPV 45
            |:.|.: ||||...|          |:.||.|..::.              :|:.:     ..||
Frog     1 MIPRVIALFVTCHFV----------LLHLPQCCGQRATGPRFLISDRDRDPQCNPHCTRPQHKPV 55

  Fly    46 CGTDGQTYPTRCHLLRAQCGGHQVSLKYSGSC-----NAC----LEAVKFARRQQERDPGYFVPR 101
            |.:||:||.:.|...||:|....:|:.:.|.|     :.|    .:|::.|::.||   ..|:|.
Frog    56 CASDGRTYESMCDYQRAKCKDATLSVTHRGRCKDAGQSKCRLERTQALEQAKKPQE---AVFIPE 117

  Fly   102 CRKDGNFAAMQCYGNNG-CWCSDSQGRPIADDNKQFRRKGKLRCRANRRDRRRLASHQIGYNPDT 165
            |.:||:|..:||:...| |||....|:|::
Frog   118 CNEDGSFTQVQCHTFTGYCWCVTPDGKPVS----------------------------------- 147

  Fly   166 SASKGSSEAGSTAHRTCSKS----DRSQFNTNLMRMFR-----NEAQSFFRQPSLSDSHILEWQF 221
                |||....|.  .||.|    ..||.|:.....||     |........|::...|:.|..
Frog   148 ----GSSVQNKTP--VCSGSVTEKPSSQGNSGRRVSFRFFLTLNSDDGSKPTPTVESRHVFEGD- 205

  Fly   222 SKLDTNGNKLLDRQEIRELKKVLRRNVKPRRCGRTFGKYCDVTKDANLNWLEWSVCFTKEFHNRS 286
               ...|...:.|.||:..... .:||.        |...|:|  |...|::
Frog   206 ---GRRGPHPILRGEIQSSDHP-SQNVG--------GGVIDIT--APTLWIK------------- 243

  Fly   287 AVVNLLASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASGSEEHEDNYEDSA 351
                              |..|.:..:|                       |.|.:|..|
Frog   244 ------------------HLVIKDAKLN-----------------------SSSVKHPAN----- 262

  Fly   352 TGYGGEEDDSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMDQSVTLEEQGHGGKSVLF 416
                                                       :|..::...|||.....:..:.
Frog   263 -------------------------------------------SCDQERQSALEEAKLNPRDGIV 284

  Fly   417 VPQCLPDGRYQRIQCYSSTSTSYCWCVNEDTGKSIPGTSVKNKRPQCDESV------AVRPMK-- 473
            :|:|.|.|.|:.:||:.  ||.|||||..|||:.:||||.:.:.|.|:...      |..|.|
Frog   285 IPECAPGGLYKPVQCHQ--STGYCWCVLVDTGRPLPGTSTRYETPVCESDARWKNTDAEDPFKDR 347

  Fly   474 ---GCTEPRKTQFLKELKAYLNTSLLPSSTTGSNSSMWK--------TDDERIATLSFVYLDKNK 527
               ||.|.:|.:|:..|...|.|.::.:..:.:.::..:        |.:||:....|..||.|.
Frog   348 ELAGCPEGKKLEFITSLLDALTTDMVQAINSAAPAAGGRFSEPDPNHTLEERVVLWYFSQLDSNG 412

  Fly   528 NKSWDRREWKNFRDLVTSASHLRRCGKKMPRYCDVNGDKKISLAEWLNCL--QATPRESATTAKP 590
            ::..:::|.|.|:..|...:..::|.::...|||:|.||.||..|...||  :..|..:|.:..|
Frog   413 SEDINKKEMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKSISFPELKGCLGVRKEPGANAGSFPP 477

  Fly   591 AQSNETASPKFQGVNP 606
            .        |..|.||
Frog   478 G--------KRPGSNP 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	14/43 (33%)
		TY	88..139	CDD:238114	16/51 (31%)
		SPARC_Ca_bdg	180..274	CDD:287550	23/102 (23%)
		SPARC_EC	<219..281	CDD:238155	11/61 (18%)
		TY	396..463	CDD:238114	26/66 (39%)
smoc1	XP_012823493.1	KAZAL_FS	47..87	CDD:238052	13/39 (33%)
		Thyroglobulin_1	95..158	CDD:278514	23/106 (22%)
		Thyroglob_assoc	159..256	CDD:293205	26/165 (16%)
		TY	263..329	CDD:238114	26/67 (39%)
		SPARC_EC	<401..468	CDD:238155	20/66 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10380
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	177	1.000	Inparanoid score	I3926
OMA	1	1.010	-	-		QHG47194
OrthoDB	1	1.010	-	-		D1057719at2759
OrthoFinder	1	1.000	-	-		FOG0004129
OrthoInspector	1	1.000	-	-		oto105578
Panther	1	1.100	-	-	LDO	PTHR12352
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2872
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080