DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1407 and ZDHHC18

DIOPT Version :9

Sequence 1:	NP_001286264.1	Gene:	CG1407 / 36043	FlyBaseID:	FBgn0033474	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_115659.1	Gene:	ZDHHC18 / 84243	HGNCID:	20712	Length:	388	Species:	Homo sapiens

Alignment Length:	397	Identity:	93/397 - (23%)
Similarity:	135/397 - (34%)	Gaps:	148/397 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 IGMIFMLLFYHLFLTLFMWSYWRTIMTSVGRIPDQWRIPDEEVSRLFRADSPDTQKRILNNFA-- 114
            |.:|..:||:.:...|...|:     |..|.:|           |....::...:|:|.|..:
Human   124 IPIIAAILFFFVMSCLLQTSF-----TDPGILP-----------RATVCEAAALEKQIDNTGSST 172

  Fly   115 -RDLPVTNRTM-NG---SVRFCEKCKIIKPDRAHHCSVCSCCVLKMDHHCPWVNNCVNFYNYKY- 173
             |..|.|...: ||   .:::|..||:.:|.|..|||||..||.:.|||||||.|||...||::
Human   173 YRPPPRTREVLINGQMVKLKYCFTCKMFRPPRTSHCSVCDNCVERFDHHCPWVGNCVGRRNYRFF 237

  Fly   174 --FVLFLGY--ALVYCLYVAFTSLHDFVEFWKVGAYDNNGYSAQGQLNASGMGRFHILFLFFIAI 234
              |:|.|.:  |.::...|...:|.                 |||....|.:.......|..:..
Human   238 YAFILSLSFLTAFIFACVVTHLTLR-----------------AQGSNFLSTLKETPASVLELVIC 285

  Fly   235 MFAI-SLVSLFGYHIYLVLVNRTTLESFRAPIFRVGGPDKNGYNLGRYANFCEVFGDDWQYWFLP 298
            .|:| |::.|.|:|.|||..|.||.|..:.                           .|.
Human   286 FFSIWSILGLSGFHTYLVASNLTTNEDIKG---------------------------SWS----- 318

  Fly   299 VFSSRGDGYSYPTSSDQSRVSTSSPTQRYDAMGDTTTSRLDGNPTDKLIGASP---LDTTNHHHN 360
              |.||...|....|.:|.::                     |....|.|..|   :|....
Human   319 --SKRGGEASVNPYSHKSIIT---------------------NCCAVLCGPLPPSLIDRRGF--- 357

  Fly   361 QSPHQVRSTSVLPTQLLQIQPPSTCRDELNERQQKLANGQSLDCSTPAAMSSPDERGVNGAAVYI 425
                 |:|.:|||:.:..        ||                  ||..:.||          .
Human   358 -----VQSDTVLPSPIRS--------DE------------------PACRAKPD----------A 381

  Fly   426 EMIGDHP 432
            .|:|.||
Human   382 SMVGGHP 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1407	NP_001286264.1	zf-DHHC	129..259	CDD:279823	47/135 (35%)
ZDHHC18	NP_115659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		zf-DHHC	191..314	CDD:279823	48/139 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..388		10/59 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157913
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740