DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1407 and ZDHHC13

DIOPT Version :9

Sequence 1:	NP_001286264.1	Gene:	CG1407 / 36043	FlyBaseID:	FBgn0033474	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens

Alignment Length:	312	Identity:	70/312 - (22%)
Similarity:	118/312 - (37%)	Gaps:	79/312 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WIPVLFITAVIAWSYYAYVVELCIRNSENRIGMIFMLL----FYHLF---LTLFMWSYWRTIMTS 79
            ::|..|:.:.:.|.:..:.:            :.|..|    ||..|   :..|::.:::|..|.
Human   346 YLPTAFLLSSVFWIFMTWFI------------LFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATD 398

  Fly    80 VGRIPDQWRIPDEEVSRLFRADSPDTQKRILNNFARDLPVTNRTMNGSVRFCEKCKIIKPDRAHH 144
            .|                |...|.:.:|..:...|....:..||      ||..|.|.||.|:.|
Human   399 PG----------------FTKASEEEKKVNIITLAETGSLDFRT------FCTSCLIRKPLRSLH 441

  Fly   145 CSVCSCCVLKMDHHCPWVNNCVNFYNYKYFVLFLGYALVYCLYVAFTSL-----HDFVEFWKVGA 204
            |.||:|||.:.|.||.|...|:.|.|:.|::.||.:..:.|.::.:.|.     |....|.:.|.
Human   442 CHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGL 506

  Fly   205 YDNNGYSAQGQLNASG--------MGRFHILFLFFIAI--MFAISLVSLFGYHIYLVLVNRTTLE 259
                 ::...|:.|..        :..||..:..|:.:  :|.|:.:.|..:       .|.:|:
Human   507 -----WTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSH-------ERISLQ 559

  Fly   260 SFRAPIFRVGGPDKNGYNLGRYANF-----CEVFG------DDWQYWFLPVF 300
            .....:.:.....|..||||...|.     |..||      .||...:..||
Human   560 KQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMVF 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1407	NP_001286264.1	zf-DHHC	129..259	CDD:279823	38/144 (26%)
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANKYR	<145..271	CDD:223738
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..559	CDD:307600	40/153 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810