DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1407 and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_001286264.1	Gene:	CG1407 / 36043	FlyBaseID:	FBgn0033474	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_766142.2	Gene:	Zdhhc17 / 320150	MGIID:	2445110	Length:	632	Species:	Mus musculus

Alignment Length:	331	Identity:	74/331 - (22%)
Similarity:	128/331 - (38%)	Gaps:	85/331 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WIPVLFITAVIAWSYYAYVVELCIRNSENRIGMIFMLLFYHLFLTLFMWSYWRTIMTSVGRIP-- 84
            |..|.|::.    |::.:.:     :|...:| |::...:.:::|.|.| :|..:......:|
Mouse   339 WATVQFLSK----SFFDHSM-----HSALPLG-IYLATKFWMYVTWFFW-FWNDLNFLFIHLPFL 392

  Fly    85 -----------DQWRIPDEEVSRLFRADSPDTQKRILNNFARDLPVTNRTMNGSVRFCEKCKIIK 138
                       ..|: .|..:.:........|...:....:.||.:          ||..|.|.|
Mouse   393 ANSVALFYNFGKSWK-SDPGIIKATEEQKKKTIVELAETGSLDLSI----------FCSTCLIRK 446

  Fly   139 PDRAHHCSVCSCCVLKMDHHCPWVNNCVNFYNYKYFVLFLGYALVYCLYVAFTSLHDFVEFWKVG 203
            |.|:.||.||:.|:.|.|||||||.|||...|::|   |:|| |.:.|::....::..|.:|  |
Mouse   447 PVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRY---FMGY-LFFLLFMICWMIYGCVSYW--G 505

  Fly   204 AYDNNGYSAQG------------------QLNASGMGRFHILFLFFIAIMFAISLVSLFGYHIYL 250
            .:....|:..|                  .||:.    ||.|   ::|::....|     |.|..
Mouse   506 LHCETTYTKDGFWTYITQIATCSPWMFWMFLNSV----FHFL---WVAVLLMCQL-----YQITC 558

  Fly   251 V------LVNRTTLESFRAPIFRVGGPDKNG--YNLGRYANF--CEVFGD---DW-QYWFLPVFS 301
            :      .:|....:.|:.....:..|..:|  .|:..:..|  |.:|..   || :.:.:....
Mouse   559 LGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQ 623

  Fly   302 SRGDGY 307
            ..|.||
Mouse   624 ISGSGY 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1407	NP_001286264.1	zf-DHHC	129..259	CDD:279823	45/153 (29%)
Zdhhc17	NP_766142.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000269\|PubMed:25253725	11..305
		ANK repeat	89..120	CDD:293786
		PHA03095	100..>352	CDD:222980	4/16 (25%)
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:372319
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		DHHC	438..568	CDD:366691	44/147 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810