DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and prkar1b

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001070091.1	Gene:	prkar1b / 767685	ZFINID:	ZDB-GENE-060929-580	Length:	380	Species:	Danio rerio

Alignment Length:	376	Identity:	147/376 - (39%)
Similarity:	214/376 - (56%)	Gaps:	24/376 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSRRIQVPEELK------------EVLLQFSISFLVEQPPDVIDYAVEYFTKLQSERPSVSHTDQ 57
            ||..::..|.||            ::|.:..::..:.:|...:.:..|:|.||:.|........|
Zfish     4 SSSNLEEDESLKGCEVFVQKHNIQQILKECIVNLCIAKPERPMKFLREHFEKLEKEECKQIMARQ 68

  Fly    58 STDDQLSVNSQDADAEPP-----VMASSRRKSVFAEAYDPEADDDDDGATAVFPKTDEQRARLVE 117
            .::.|  .:|.|.:..||     |.|..||..|.||.|..|  |.......|.||..:....|.:
Zfish    69 KSNSQ--SDSHDDEVSPPPPNPVVKARRRRGGVSAEVYTEE--DAVSYVRKVIPKDYKTMTALAK 129

  Fly   118 SVKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTYN 182
            ::...:||..|:..:.:.:.||||......|:.:|:|||:|||||||:.|...||:|.:.:.:..
Zfish   130 AISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGDEGDNFYVIDQGEVDVYVNGEWVTSIG 194

  Fly   183 HTGLFGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQ 247
            ..|.||||||:|..||||||:|:|...||.:||.::||||:.|..||||||||.|:.|.:|::|.
Zfish   195 EGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 259

  Fly   248 NYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRMDQDDAE--VEISQLGKGQYFG 310
            .:||:.:||||....:::||:|:.||:..|..:.|.|||.||...:.|.|  ||:.:||...|||
Zfish   260 KWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGTASVLQRRSDNEEYVEVGRLGPSDYFG 324

  Fly   311 ELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYES 361
            |:||:.:|||||:|.|. |.:|...||...|||:||||.:|:||||..|.|
Zfish   325 EIALLLNRPRAATVVAR-GPLKCVKLDRPRFERVLGPCSEILKRNIQRYNS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	9/49 (18%)
		CAP_ED	124..233	CDD:237999	52/108 (48%)
		CAP_ED	242..356	CDD:237999	53/115 (46%)
prkar1b	NP_001070091.1	DD_RIbeta_PKA	10..63	CDD:213049	10/52 (19%)
		CAP_ED	136..245	CDD:237999	52/108 (48%)
		CAP_ED	254..369	CDD:237999	53/115 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860