DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pka-R2 and pnpla6

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	XP_005160109.1	Gene:	pnpla6 / 560986	ZFINID:	ZDB-GENE-050107-4	Length:	1343	Species:	Danio rerio

Alignment Length:	379	Identity:	85/379 - (22%)
Similarity:	146/379 - (38%)	Gaps:	90/379 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PSVSHTDQSTDD----QLSVNSQDADAEPPVMASSR-RKSVFAEAYDPEADDDDDGATAVFPKTD 109
            |::|.|.....|    |.|:.| |.|     ||..| |.||.||          ||..|.   |.
Zfish   374 PTLSRTISMPVDIAGMQKSLRS-DFD-----MAYERGRISVSAE----------DGVPAF---TK 419

  Fly   110 EQRARLV-------------------------ESVKNVLLFRSLEKE--QMNQVLD-AMFERKV- 145
            |||.|.|                         :...|..:|...:||  ::.::.| ::...:|
Zfish   420 EQRERKVTVDEVPSGVYLYPEEESGMDIFSSFQGRPNATVFEEAQKEILRLMKIEDPSLLNGRVT 484

  Fly   146 ----QPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTYNHTGLF--------GELALLYNMPR 198
                :.|..:.||||...:.:.:.||...||  .|.|:......||        |:||:|...|.
Zfish   485 FHHAKAGSVLARQGDQDVSLHFVLSGCLHVY--QKMIDKQEAVCLFVTQPGEMVGQLAVLTGEPL 547

  Fly   199 AATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSY 263
            ..|::||.......:.:..|..|:       |:....:|::...:....:.....:..|:...:.
Zfish   548 IFTIKAERDCTFLKISKSEFYEIM-------REQPSVVLSAAHTVAIRMSAFVRQMDFAIDWMAV 605

  Fly   264 DNGERIIKQGDAADGMYFIEEGTV-SVRMDQDDAEVEISQLGKGQYFGELALVTHRPRAASVYAT 327
            :.|..:.:|.|.:|..|.:..|.: ||....:..:..:.:.|:|...|.:..:|.:|||.:|:|
Zfish   606 EAGRALYRQDDQSDCTYIVLNGRLRSVIRKANGKKELVGEYGRGDLIGVVEALTRQPRATTVHA- 669

  Fly   328 GGVVKLAFLDVKAFERLLGP--CMDIMKRNIDDYESQLVKIFGSK--NNITDTR 377
                      |:..|.:..|  .::.:||......::|:.:.|.|  .|:...|
Zfish   670 ----------VRDTELVKLPEGTLNNIKRRYPQVVTRLIHLLGQKILGNLQQPR 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046
		CAP_ED	124..233	CDD:237999	29/124 (23%)
		CAP_ED	242..356	CDD:237999	23/116 (20%)
pnpla6	XP_005160109.1	TM_EGFR-like	31..64	CDD:213052
		Crp	164..>302	CDD:223736
		CAP_ED	170..291	CDD:237999
		Crp	466..>596	CDD:223736	28/138 (20%)
		CAP_ED	467..577	CDD:237999	26/118 (22%)
		CAP_ED	590..698	CDD:237999	23/118 (19%)
		Crp	605..>706	CDD:223736	25/111 (23%)
		Pat_PNPLA6_PNPLA7	921..1226	CDD:132864
		RssA	926..1216	CDD:224666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900