DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and pnpla7b

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	XP_692276.5	Gene:	pnpla7b / 503936	ZFINID:	ZDB-GENE-050309-66	Length:	1340	Species:	Danio rerio

Alignment Length:	353	Identity:	74/353 - (20%)
Similarity:	148/353 - (41%)	Gaps:	54/353 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FTKLQSERPSVSHTDQSTDDQ---LSVNSQDADAEPPVMASSRRKSVFAEAYDPEADDDDDGATA 103
            |.|.:|....:..|...:.|.   ...:|::|.:.|..:..|.||......:.|         :|
Zfish   388 FRKSRSLSTPLESTHAGSPDHNMTFDRSSKEAPSSPIAIQKSNRKKSVTMHHSP---------SA 443

  Fly   104 VFPKTDE--QRARLVESVKNVL-------LFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGD 159
            ||..:|.  ..:.:..|..|.:       |.:.::.:..|.:.|.:..|:|:.|..:..:||...
Zfish   444 VFHYSDTGGHSSHIHHSKVNAIFQAAKRDLLKIIQLQDPNLLEDRVTLRQVKAGSVVASEGDQDV 508

  Fly   160 NFYVIESGVYKVYINDKHINTYNHTGLF--------GELALLYNMPRAATVQAETSGLLWAMDRQ 216
            :...:.||...||  .:.|:....:.||        |.||:|...|...:|:|:......::.:.
Zfish   509 SVQFVISGTLHVY--QRLIDREEQSCLFVAHPGEMVGHLAVLTGEPLIFSVRAQRDCCFLSISKT 571

  Fly   217 TFRRILLKSAFRKRKMYEELLN-SVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMY 280
            .|..|:       |.....:|| :..:::.:.::.| .:..||...:.:.|..:.:|||.:|..:
Zfish   572 HFYEIM-------RAEPRMVLNVAHTVVRRVSSFVR-QIDFALDWMALEAGRAVYRQGDKSDSTF 628

  Fly   281 FIEEGTVSVRMDQDDAEVEIS-QLGKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFE-- 342
            .:..|.:...:.:||.:.|:: :.|:|...|.:..:||..||.:|:|           |:..|
Zfish   629 IVLSGRLRSVIMKDDGKKELAGEYGRGDLIGVVEALTHLNRATTVHA-----------VRDSELA 682

  Fly   343 RLLGPCMDIMKRNIDDYESQLVKIFGSK 370
            :|....::.:||......::|:.:.|.|
Zfish   683 KLPEGALNSIKRKYPQVVTRLIHLLGQK 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	3/6 (50%)
		CAP_ED	124..233	CDD:237999	25/116 (22%)
		CAP_ED	242..356	CDD:237999	26/116 (22%)
pnpla7b	XP_692276.5	Crp	164..354	CDD:223736
		CAP_ED	170..291	CDD:237999
		Crp	470..>602	CDD:223736	28/141 (20%)
		CAP_ED	473..583	CDD:237999	25/118 (21%)
		Crp	596..>718	CDD:223736	29/127 (23%)
		CAP_ED	596..704	CDD:237999	26/119 (22%)
		Pat_PNPLA6_PNPLA7	927..1232	CDD:132864
		RssA	932..1234	CDD:224666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900