DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and Pka-R1

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	149/378 - (39%)
Similarity:	214/378 - (56%)	Gaps:	28/378 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSDSSRRIQ--------VPEE--LKEVLLQFSISFLVEQPPDVIDY----AVEYFTKLQSERPS 51
            :|.|:..|::        :|||  :.:..||..:|.|..:....::.    ..|...||.:.|..
  Fly    92 LSLDAVHRMRHVRTSCTTIPEEDAVSDRSLQIHLSTLAREREQELELERQREREEQVKLDASRQV 156

  Fly    52 VSHTDQSTDDQLSVNSQDADAEPPVMASSRRKSVFAEAYDPEADDDDDGATAVFPKTDEQRARLV 116
            :     |.||...::.....|.|||   .||..:.||....|  |..:....|.||..:....|.
  Fly   157 I-----SPDDCEDLSPMPQTAAPPV---RRRGGISAEPVTEE--DATNYVKKVVPKDYKTMNALS 211

  Fly   117 ESVKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTY 181
            :::...:||..|::.:.:.:.||||......|:.||:|||:|||||||:.|...|::|.:.:.|.
  Fly   212 KAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSELVTTI 276

  Fly   182 NHTGLFGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKAL 246
            :..|.||||||:|..||||||:|:|...||.:||.::||||:.|..||||||||.|:.|.:|::|
  Fly   277 SEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESL 341

  Fly   247 QNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSV---RMDQDDAEVEISQLGKGQY 308
            ..:||:.:||:|.:.|:|:||.|:|||.|.|..|.|.||...|   |.:|.:...|:.:||...|
  Fly   342 DKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQQRSEQGEDPAEVGRLGSSDY 406

  Fly   309 FGELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYES 361
            |||:||:..|||||:|.|. |.:|...||...|||:||||.||:||||..|.|
  Fly   407 FGEIALLLDRPRAATVVAR-GPLKCVKLDRARFERVLGPCADILKRNITQYNS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	10/43 (23%)
		CAP_ED	124..233	CDD:237999	53/108 (49%)
		CAP_ED	242..356	CDD:237999	55/116 (47%)
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	59/125 (47%)
		CAP_ED	219..328	CDD:237999	53/108 (49%)
		Crp	331..>442	CDD:223736	49/111 (44%)
		CAP_ED	337..453	CDD:237999	55/116 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443728
Domainoid	1	1.000	66	1.000	Domainoid score	I3580
eggNOG	1	0.900	-	-		E1_COG0664
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I1118
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	1	1.000	-	-		otm46748
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
	11	10.730