DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and PNPLA7

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	XP_006717165.1	Gene:	PNPLA7 / 375775	HGNCID:	24768	Length:	1343	Species:	Homo sapiens

Alignment Length:	418	Identity:	92/418 - (22%)
Similarity:	156/418 - (37%)	Gaps:	119/418 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VEQPPDVIDYAVEYFTKLQSERPSVSHTDQSTDDQLSVNSQDADAEP------PVMASSRRKSVF 86
            :::||           :||....|..|.          ..:.|.|.|      .|.|.|.||.:.
Human   349 LKKPP-----------RLQESCDSADHG----------GGRPAAAGPLLKRSHSVPAPSIRKQIL 392

  Fly    87 AEAYDPEADDDDDGA------------------TAVFPKTDEQRARLV--ESVKNVL-------- 123
            .|...|.|.|.|..|                  ..||..:||.....|  :|.|:|:
Human   393 EELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVAEIPSTV 457

  Fly   124 -------------------LFRSLEKEQM-------NQVLD---AMFERKVQPGDFIIRQGDDGD 159
                               :||:.:|:.:       :.:||   |:..  |..|..:.||||...
Human   458 SQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLH--VPAGTVVSRQGDQDA 520

  Fly   160 NFYVIESGVYKVYINDKHINTYNHTGLF--------GELALLYNMPRAATVQAETSGLLWAMDRQ 216
            :...:.||:..||  .:.|.:...|.||        |:||:|...|...||:|.......::.:.
Human   521 SILFVVSGLLHVY--QRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKA 583

  Fly   217 TFRRILLKSAFRKRKMYEELLN-SVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMY 280
            .|..|:       ||....:|. :..::|.:.::.| .:..||.....:.|..|.:|||.:|..|
Human   584 HFYEIM-------RKQPTVVLGVAHTVVKRMSSFVR-QIDFALDWVEVEAGRAIYRQGDKSDCTY 640

  Fly   281 FIEEGTVSVRMDQDDAEVEIS-QLGKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFE-- 342
            .:..|.:...:.:||.:..:: :.|:|...|.:..:||:.||.:|:|           |:..|
Human   641 IMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHA-----------VRDSELA 694

  Fly   343 RLLGPCMDIMKRNIDDYESQLVKIFGSK 370
            :|....:..:||......::|:.:.|.|
Human   695 KLPAGALTSIKRRYPQVVTRLIHLLGEK 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	4/20 (20%)
		CAP_ED	124..233	CDD:237999	32/126 (25%)
		CAP_ED	242..356	CDD:237999	28/116 (24%)
PNPLA7	XP_006717165.1	Crp	164..>306	CDD:223736
		CAP_ED	170..291	CDD:237999
		Crp	485..>614	CDD:223736	32/140 (23%)
		CAP_ED	485..593	CDD:237999	29/118 (25%)
		Crp	607..>724	CDD:223736	30/128 (23%)
		CAP_ED	608..716	CDD:237999	27/119 (23%)
		Pat_PNPLA6_PNPLA7	937..1242	CDD:132864
		RssA	942..1243	CDD:224666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900