DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and Pkg21D

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster

Alignment Length:	324	Identity:	82/324 - (25%)
Similarity:	160/324 - (49%)	Gaps:	26/324 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SVSHTDQSTDDQL-------SVNSQDADAEPPVMASSRRKSVFAEAYDPEADDDDDGATAVFPKT 108
            |.|.:.:::.|::       ::..|...||..|.:..:..|:....|:.:..|
  Fly   120 SASPSGRTSADEVRPKAMPAAIKKQGVSAESCVQSMQQSYSIPIPKYEKDFSD------------ 172

  Fly   109 DEQRARLVESVKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYI 173
               :.::.:::.:....::::..|:.:::|:|:.:.:..|:|:||:|:.|.:.||..:|.:.|..
  Fly   173 ---KQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQ 234

  Fly   174 NDKHINTYNHTGLFGELALLYNMPRAATVQA-ETSGLLWAMDRQTFRRILLKSAFRKRKMYEELL 237
            ..|.::.......|||||:|||..|.|:::. ..:..:|.:||:.|::|::.:..::.:.....|
  Fly   235 QGKVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFL 299

  Fly   238 NSVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRM---DQDDAEVE 299
            .|||:|..|.......:||.|..:.|..|..||:||.|.|..:.|.:|.|.|..   .....|.|
  Fly   300 RSVPLLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETE 364

  Fly   300 ISQLGKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYESQL 363
            :..|.:|.||||.||:....|.|::.|....|:...||..:|:||:|...::.:::..|...:|
  Fly   365 LRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046
		CAP_ED	124..233	CDD:237999	29/109 (27%)
		CAP_ED	242..356	CDD:237999	37/116 (32%)
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	60/202 (30%)
		CAP_ED	185..285	CDD:237999	29/99 (29%)
		CAP_ED	304..419	CDD:237999	37/114 (32%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I744
eggNOG	1	0.900	-	-		E1_COG0664
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810