DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and Pnpla7

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	XP_036017642.1	Gene:	Pnpla7 / 241274	MGIID:	2385325	Length:	1384	Species:	Mus musculus

Alignment Length:	332	Identity:	78/332 - (23%)
Similarity:	140/332 - (42%)	Gaps:	62/332 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TDDQLSVNSQDADAEPPVMASSRRKSVFAEAYDPEADDDDDGATAVFPKTDEQRARLVESVKNVL 123
            :|:||. ||         :||..:|||.||.           .:|:|..::..|.......|...
Mouse   432 SDEQLG-NS---------LASKSKKSVVAET-----------PSAIFHYSENFRDETGACGKTDA 475

  Fly   124 LFRSLEKEQMN-------QVLDAMFE-RKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINT 180
            :||:..|:.:.       .:||.... ..|..|..:.:|||...|...:.||:..||  .:.|::
Mouse   476 IFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVY--QQKIDS 538

  Fly   181 YNHTGLF--------GELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELL 237
            ...|.||        |:||:|...|...|::|.......::.:..|..|:       ||..:.:|
Mouse   539 LEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIM-------RKRPDVVL 596

  Fly   238 N-SVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSVRMDQDDAEVEIS 301
            . :..::|.:.::.| .:..||.....:.|..|.:|||.:|..|.:..|.:...:.:||.:..::
Mouse   597 GVAHTVVKRMSSFVR-QIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLA 660

  Fly   302 -QLGKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFE--RLLGPCMDIMKRNIDDYESQL 363
             :.|:|...|.:..:||:.||.:|:|           |:..|  :|....:..:||......::|
Mouse   661 GEYGRGDLVGVVETLTHQARATTVHA-----------VRDSELAKLPAGALTSIKRRYPQVVTRL 714

  Fly   364 VKIFGSK 370
            :.:.|.|
Mouse   715 IHLLGEK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046
		CAP_ED	124..233	CDD:237999	30/124 (24%)
		CAP_ED	242..356	CDD:237999	28/116 (24%)
Pnpla7	XP_036017642.1	CAP_ED	170..294	CDD:237999
		CAP_ED	484..594	CDD:237999	27/118 (23%)
		CAP_ED	607..715	CDD:237999	27/119 (23%)
		Pat_PNPLA6_PNPLA7	944..1249	CDD:132864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900