DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and Prkg1

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_035290.1	Gene:	Prkg1 / 19091	MGIID:	108174	Length:	686	Species:	Mus musculus

Alignment Length:	388	Identity:	117/388 - (30%)
Similarity:	188/388 - (48%)	Gaps:	47/388 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EELKEVLLQFSISFLVEQPPDVIDYAVEYFTKLQSE--------RPSVSHTDQSTDDQLSVNSQD 69
            |||::      ...|:::....:|...|...|||:|        ||:.....:.:...|
Mouse    16 EELRQ------RDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTL------ 68

  Fly    70 ADAEPPVMASSRRKSVFAEAYDPEADDDDDGATAV---FPKTDEQRARLVESVKNVLLFRSLEKE 131
             ..||    .::|:::.||   |.|.|..|.:...   :||:.:.:..:.|::.:....::||..
Mouse    69 -QGEP----RTKRQAISAE---PTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELS 125

  Fly   132 QMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTYNHTGLFGELALLYNM 196
            |:.:::|.|:..:......||::||.|...||:|.|..:|......:.|.....:|||||:|||.
Mouse   126 QIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNC 190

  Fly   197 PRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSK 261
            .|.|||:...:..|||:|||.|:.|::::...|...|.|.|.|||..::|.:.....|||.|...
Mouse   191 TRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEET 255

  Fly   262 SYDNGERIIKQGDAADGMYFIEEGTVSVRMDQDDAE--VEISQLGKGQYFGELALVTHRPRAASV 324
            .|:|||.||:||...|..:.|.:|.|:|..:...:|  |.:..||||.:|||.||.....|.|:|
Mouse   256 HYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANV 320

  Fly   325 YATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDD------YESQL-----VKIFGSKNNITDT 376
            .|...|..|. :|..:|:.|:|...|:..:..:|      ||::.     :|:  |..||.||
Mouse   321 IAAEAVTCLV-IDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKL--SDFNIIDT 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	10/43 (23%)
		CAP_ED	124..233	CDD:237999	37/108 (34%)
		CAP_ED	242..356	CDD:237999	40/115 (35%)
Prkg1	NP_035290.1	DD_cGKI-beta	4..55	CDD:213375	10/44 (23%)
		Crp	116..>218	CDD:223736	36/101 (36%)
		CAP_ED	118..227	CDD:237999	37/108 (34%)
		CAP_ED	237..341	CDD:237999	38/104 (37%)
		PTZ00263	368..676	CDD:140289	6/15 (40%)
		STKc_cGK	381..641	CDD:270724	117/388 (30%)
		S_TK_X	636..>679	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810