DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and Prkar2a

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_032950.1	Gene:	Prkar2a / 19087	MGIID:	108025	Length:	402	Species:	Mus musculus

Alignment Length:	397	Identity:	195/397 - (49%)
Similarity:	268/397 - (67%)	Gaps:	31/397 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVPEELKEVLLQFSISFLVEQPPDVIDYAVEYFTKLQSER----------PSVSHTDQST---- 59
            ||:|..|.|:|..:::..|.:||||::|:||||||:|:..|          |:..||.:|:
Mouse     4 IQIPAGLTELLQGYTVEVLRQQPPDLVDFAVEYFTRLREARRQESDTFIVSPTTFHTQESSAVPV 68

  Fly    60 ---DDQLSVNSQDADAEPPVMAS-SRRKSVFAEAYDPEADDDDDGATAVFPKTDEQRARLVESVK 120
               |.:...:|:|||.|.||.:. :||.||.||.::|:.:::|:....|.|||||||.||.|:.|
Mouse    69 IEEDGESDSDSEDADLEVPVPSKFTRRVSVCAETFNPDEEEEDNDPRVVHPKTDEQRCRLQEACK 133

  Fly   121 NVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYI----NDKHINTY 181
            ::|||::|::||::||||||||:.|:..:.:|.||||||||||||.|.|.:.:    ..:.:..|
Mouse   134 DILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQY 198

  Fly   182 NHTGLFGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKAL 246
            ::.|.||||||:||.|||||:.|.:.|.||.:||.|||||::|:..:||||:|..:.|||:.|:|
Mouse   199 DNRGSFGELALMYNTPRAATIIATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSL 263

  Fly   247 QNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSV--------RMDQDDAEVEISQL 303
            :..|||.:.|.:..|.|.:|||||.||:.||..|.||.|.||:        ..:..:.||||:..
Mouse   264 EMSERMKIVDVIGEKIYKDGERIIAQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHC 328

  Fly   304 GKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYESQLVKIFG 368
            .||||||||||||::|||||.||.|. ||...:||:|||||||||||||||||..||.||||:||
Mouse   329 HKGQYFGELALVTNKPRAASAYAVGD-VKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFG 392

  Fly   369 SKNNITD 375
            |..::.|
Mouse   393 SNLDLMD 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	17/37 (46%)
		CAP_ED	124..233	CDD:237999	59/112 (53%)
		CAP_ED	242..356	CDD:237999	66/121 (55%)
Prkar2a	NP_032950.1	DD_RIIalpha_PKA	4..44	CDD:213050	19/39 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..84		5/21 (24%)
		CAP_ED	137..249	CDD:237999	58/111 (52%)
		CAP_ED	259..380	CDD:237999	66/121 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850635
Domainoid	1	1.000	93	1.000	Domainoid score	I7545
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3064
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	1	1.000	-	-		otm43151
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	1	1.100	-	-	O	PTHR11635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800