DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and Prkar1a

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001300902.1	Gene:	Prkar1a / 19084	MGIID:	104878	Length:	381	Species:	Mus musculus

Alignment Length:	383	Identity:	146/383 - (38%)
Similarity:	220/383 - (57%)	Gaps:	30/383 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSDSSRRIQVPEELKE-----------VLLQFSI-SFLVEQPPDVIDYAVEYFTKLQSERPSVS 53
            |:|.|....:....|:|           .||:.|| .....:|...:.:..|||.:|:.|.....
Mouse     1 MASGSMATSEEERSLRECELYVQKHNIQALLKDSIVQLCTTRPERPMAFLREYFERLEKEEARQI 65

  Fly    54 HTDQSTDDQLSVNSQDADAEPP-----VMASSRRKSVFAEAYDPEADDDDDGAT---AVFPKTDE 110
            ...|.|.  :..:|::.:..||     |....||.::.||.|     .::|.|:   .|.||..:
Mouse    66 QCLQKTG--IRTDSREDEISPPPPNPVVKGRRRRGAISAEVY-----TEEDAASYVRKVIPKDYK 123

  Fly   111 QRARLVESVKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYIND 175
            ..|.|.::::..:||..|:..:.:.:.||||......|:.:|:|||:|||||||:.|...||:|:
Mouse   124 TMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNN 188

  Fly   176 KHINTYNHTGLFGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSV 240
            :...:....|.||||||:|..||||||:|:|:..||.:||.::||||:.|..||||||||.|:.|
Mouse   189 EWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV 253

  Fly   241 PMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSV--RMDQDDAEVEISQL 303
            .:|::|..:||:.:||||....:::|::|:.||:..|..:.|.|||.:|  |..:::..||:.:|
Mouse   254 SILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRL 318

  Fly   304 GKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYES 361
            |...||||:||:.:|||||:|.|. |.:|...||...|||:||||.||:||||..|.|
Mouse   319 GPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVLGPCSDILKRNIQQYNS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	11/49 (22%)
		CAP_ED	124..233	CDD:237999	52/108 (48%)
		CAP_ED	242..356	CDD:237999	51/115 (44%)
Prkar1a	NP_001300902.1	Dimerization and phosphorylation	2..136		32/140 (23%)
		DD_RIalpha_PKA	14..63	CDD:213048	12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..96		4/22 (18%)
		Pseudophosphorylation motif	96..100		2/3 (67%)
		CAP_ED	137..246	CDD:237999	52/108 (48%)
		CAP_ED	255..370	CDD:237999	51/115 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760