DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and kin-2

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001076771.1	Gene:	kin-2 / 180864	WormBaseID:	WBGene00002190	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	357	Identity:	137/357 - (38%)
Similarity:	204/357 - (57%)	Gaps:	16/357 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RRIQVPEELKEVLLQFSISFLVEQPPDVIDYAVEYFTKLQSERPSVSHTDQSTDDQLSVNSQDAD 71
            :|..:.:.:||.:    :...:.:|.:.:.:..::|.||..:|........:.||      .|..
Worm    28 QRHNIQQLVKEAI----VVLCIHKPDNPVLFLKDHFEKLNEQRAQEGGNPDAADD------DDII 82

  Fly    72 AEPPVMASSRRKSVFAEAYDPEADDDDDGATAVFPKTDEQRARLVESVKNVLLFRSLEKEQMNQV 136
            .|||..:..||..:.||   |..:||.:....|.||.|..|..|..:::..|||..||:::...:
Worm    83 VEPPKRSGGRRTGISAE---PIKEDDTEYKKVVIPKDDATRRSLESAMRKNLLFAHLEEDEQKTM 144

  Fly   137 LDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTYNHTGLFGELALLYNMPRAAT 201
            .||||..:...|:.||.||::|||||||:.|...||:|.:::.|.|..|.||||||:|..|||||
Worm   145 YDAMFPVEKSAGETIIEQGEEGDNFYVIDKGTVDVYVNHEYVLTINEGGSFGELALIYGTPRAAT 209

  Fly   202 VQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSYDNG 266
            |.|:|...|||:||.|:||||:.|..:|||||:|.|:.|.:|..|..:||.|:||||....::.|
Worm   210 VIAKTDVKLWAIDRLTYRRILMGSVTKKRKMYDEFLSKVQILADLDQWERANVADALERCDFEPG 274

  Fly   267 ERIIKQGDAADGMYFIEEGTVSV-RMDQDDAEVE-ISQLGKGQYFGELALVTHRPRAASVYATGG 329
            ..:::||...|..:.|.||..:| :...|||..: :..||...||||:||:..|||||:|.|...
Worm   275 THVVEQGQPGDEFFIILEGEANVLQKRSDDAPFDVVGHLGMSDYFGEIALLLDRPRAATVVAKTH 339

  Fly   330 VVKLAFLDVKAFERLLGPCMDIMKRNIDDYES 361
             :|...||...|||::||..:|:||::.:|.|
Worm   340 -LKCIKLDRNRFERVMGPVREILKRDVSNYNS 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	6/37 (16%)
		CAP_ED	124..233	CDD:237999	56/108 (52%)
		CAP_ED	242..356	CDD:237999	46/115 (40%)
kin-2	NP_001076771.1	DD_RI_PKA	23..66	CDD:213044	7/41 (17%)
		Crp	126..>281	CDD:223736	72/154 (47%)
		CAP_ED	132..241	CDD:237999	56/108 (52%)
		Crp	244..>367	CDD:223736	48/123 (39%)
		CAP_ED	250..363	CDD:237999	44/113 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860