DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and pkg-2

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_741467.1	Gene:	pkg-2 / 177659	WormBaseID:	WBGene00015650	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	379	Identity:	87/379 - (22%)
Similarity:	152/379 - (40%)	Gaps:	85/379 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 VMASSRRKSVFAEAYDPEADD----DDDGATAVFPKTDEQRARLV--------ESVKNVL----L 124
            ::|....|....|....|.|:    :....||:..:.|.|..|.:        |::.|.|    .
Worm     8 LLAELELKDDIIEQLRKELDEYRMMNTTRKTAISSEPDIQVKRPIIGKSDAAFETIGNALRLNSF 72

  Fly   125 FRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTYNHTGLFGE 189
            .|:|:..|:.::..||:..:|..|..||||||.|...|||:.|..:|..:::.:.|.....||||
Worm    73 LRNLDATQIEKISSAMYPVEVPAGAIIIRQGDLGSIMYVIQEGKVQVVKDNRFVRTMEDGALFGE 137

  Fly   190 LALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNL 254
            ||:|::..|.|||:|..|..|||::|..|..|:::||..|...::..|..............:.:
Worm   138 LAILHHCERTATVRAIESCHLWAIERNVFHAIMMESAREKTMSFKRHLKYSARFGGYPEEVLLRI 202

  Fly   255 ADALVSKSYDNGERII-----------------KQGDAAD-----------------GMYFIEEG 285
            |:......||..|.::                 .||:.:.                 ..:|:.||
Worm   203 AEFCTEMRYDAREELVVKPQYVYLVCRGSVLCDDQGEVSKIVAGQDFELRCGRKGRFERFFVLEG 267

  Fly   286 ---TVSVRMDQ----------------------DDAEVE------ISQLGKGQYFGELALVTHRP 319
               .:.:.::|                      ::|:||      :|.||.|. ||.:.||  |.
Worm   268 PAHLIKMHVEQLCKALDTTDLDDEIRPRASSTIEEADVELEDLQRVSTLGMGG-FGRVELV--RS 329

  Fly   320 RAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYESQLVKIFGSKNNI 373
            .::..||...:.|...::.|....::.....:|:.: :||..::.|.:.....|
Worm   330 ASSRTYALKIMNKAHIVETKQESHVVSERRILMQCD-NDYIVRMYKTYRDSEKI 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046
		CAP_ED	124..233	CDD:237999	42/108 (39%)
		CAP_ED	242..356	CDD:237999	27/178 (15%)
pkg-2	NP_741467.1	Crp	66..>173	CDD:223736	40/106 (38%)
		CAP_ED	72..173	CDD:237999	39/100 (39%)
		PTZ00263	295..599	CDD:140289	21/92 (23%)
		STKc_cGK	316..572	CDD:270724	17/71 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910