DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-R2 and prkg2

DIOPT Version :9

Sequence 1:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	XP_021331649.1	Gene:	prkg2 / 100125912	ZFINID:	ZDB-GENE-060531-80	Length:	769	Species:	Danio rerio

Alignment Length:	299	Identity:	92/299 - (30%)
Similarity:	157/299 - (52%)	Gaps:	17/299 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SRRKSVFA-EAYDPEADDDDDGATAVFPKTDEQRARL--VESVKNVL--------LFRSLEKEQM 133
            :|||...| .:.:|.:...|...   .||...:.||:  .:|||.:|        ..|.||.:|:
Zfish   123 NRRKGAKAGVSAEPSSRTYDSSG---IPKFYFESARVWKEQSVKKLLTDALNKNQYLRRLEVQQV 184

  Fly   134 NQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTYNHTGLFGELALLYNMPR 198
            ..:::.|:||..|.|:::|:||:.|::.:|:..|...||.::|.:.:......|||||:|||..|
Zfish   185 KDMVECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQHNKLLTSIAVWTTFGELAILYNCTR 249

  Fly   199 AATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSY 263
            .|:|:|.::...||:||:.|..|:..:|..:.:.|...|.||.:|.:|...:...:.|.|..:.|
Zfish   250 TASVKAASNVKTWALDREVFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYY 314

  Fly   264 DNGERIIKQGDAADGMYFIEEGTVSVRMDQDDAEVE--ISQLGKGQYFGELALVTHRPRAASVYA 326
            :.|:.||::|:..:..|.|..|.:.|.....|.|..  |:.||||.||||.||::...|:|::.|
Zfish   315 NKGDYIIREGEEGNTFYIIANGKIKVTQSTQDHEEPQIINTLGKGDYFGEKALISDDVRSANIIA 379

  Fly   327 TGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYESQLVK 365
            ....|:...:|.:.|.:.:| ..|.:|:.:..|...|.:
Zfish   380 EEDGVECLVIDRETFSQTVG-TFDELKKYLQSYVDSLAR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046
		CAP_ED	124..233	CDD:237999	37/108 (34%)
		CAP_ED	242..356	CDD:237999	35/115 (30%)
prkg2	XP_021331649.1	CAP_ED	176..284	CDD:237999	37/107 (35%)
		CAP_ED	293..408	CDD:237999	35/115 (30%)
		STKc_cGK	466..725	CDD:270724
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810