DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TER94 and TRIP13

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_004228.1	Gene:	TRIP13 / 9319	HGNCID:	12307	Length:	432	Species:	Homo sapiens

Alignment Length:	465	Identity:	110/465 - (23%)
Similarity:	169/465 - (36%)	Gaps:	124/465 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 HGEVERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFG-----RFDREIDIGIPDATG 398
            |.||.:|..|      ...|:..:|.|....||.|.:      ||     .||.      |..|.
Human    22 HVEVHQRGSS------TAKKEDINLSVRKLLNRHNIV------FGDYTWTEFDE------PFLTR 68

  Fly   399 RLEVLRIHTKNMKLHDD--VDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDA 461
            .::.:.|....:|:.|.  :||                |.|:.|        :.:..|.:|...:
Human    69 NVQSVSIIDTELKVKDSQPIDL----------------SACTVA--------LHIFQLNEDGPSS 109

  Fly   462 EVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFL 526
            |   :|....||...|.....|:|....:       |..:.....||..|.:.|...:...||.:
Human   110 E---NLEEETENIIAANHWVLPAAEFHGL-------WDSLVYDVEVKSHLLDYVMTTLLFSDKNV 164

  Fly   527 KFGMQP-SRGVLFYGPPGCGKTLLAKAIANEC---------QANFISVKGPELLTMWFGESEANV 581
            ...:.. :|.||.:||||.|||.|.||:|.:.         ....|.:....|.:.||.||...|
Human   165 NSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLV 229

  Fly   582 RDIFDKARSA-----APCVLFFDELDSIAKARGG-NVGDAGGAADRVINQILTEMDGMGAKKNVF 640
            ..:|.|.:..     |...:..||::|:..||.. ..|.....|.||:|.:||::|.:....||.
Human   230 TKMFQKIQDLIDDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVV 294

  Fly   641 IIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANL--------------RKSPLA-K 690
            |:..:|..:.||.|.:  .|.|...||..|   |..||.|..|              |:..|. :
Human   295 ILTTSNITEKIDVAFV--DRADIKQYIGPP---SAAAIFKIYLSCLEELMKCQIIYPRQQLLTLR 354

  Fly   691 EVD---------------LTYIAKVTQGFSGADLTEICQRACKL--------------AIRQAIE 726
            |::               |..|::.::|.||..|.::...|..|              |:..|::
Human   355 ELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVD 419

  Fly   727 AEIRREKERA 736
            .:....|:.|
Human   420 KQFEERKKLA 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	110/465 (24%)
		CDC48_N	47..129	CDD:280513
		CDC48_2	153..213	CDD:215011
		AAA	263..392	CDD:278434	15/57 (26%)
		AAA	536..669	CDD:278434	47/147 (32%)
		Vps4_C	<741..783	CDD:286426
TRIP13	NP_004228.1	SpoVK	<136..360	CDD:223540	64/228 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810