DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and PEX1

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_012724.1	Gene:	PEX1 / 853636	SGDID:	S000001680	Length:	1043	Species:	Saccharomyces cerevisiae

Alignment Length:	961	Identity:	242/961 - (25%)
Similarity:	393/961 - (40%)	Gaps:	249/961 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EKMKPKDSFDKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFRGDTVILKGK 84
            ::::|.....:..|.:..::..|....||:..|..:.:.:::     |...:||.:  .|||
Yeast   162 DRVEPSMKSARITDGSLVVVAPKVNKTRLVKAEYGHSNKTIL-----KNGAIQLLK--KVIL--- 216

  Fly    85 RRKETVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSD---------VVSVQSC------------- 127
              :.|||             :|:....|...|::||         ..|:..|
Yeast   217 --RSTVC-------------KMDFPKDNLFVVYISDGAQLPSQKGYASIVKCSLRQSKKSDSDNK 266

  Fly   128 ----PDVKYGKRVRI-LPIDESTEGVTGNLFEIY---------LKPYFLEAYRPIHMGDNFIVRA 178
                |..|.|..::. ..|.|:...::.:|::.:         :|..||:      |....|:..
Yeast   267 SVGIPSKKIGVFIKCDSQIPENHIALSSHLWDAFFTHPMNGAKIKLEFLQ------MNQANIISG 325

  Fly   179 AMRPIEFK-----VVLTDPEPY------------CIVAPETVIFCDGDPIKREEEEE---SLNAV 223
            ....:..|     |.....:.|            .|:..|.:|.    .||:.|.|:   :||.:
Yeast   326 RNATVNIKYFGKDVPTKSGDQYSKLLGGSLLTNNLILPTEQIII----EIKKGESEQQLCNLNEI 386

  Fly   224 GYDDIGGCRKQLA--QIKEMVELPLRHPSLFKAIG------------------------------ 256
            ..:.:.....|:.  ::|:::|..|......|..|
Yeast   387 SNESVQWKVTQMGKEEVKDIIERHLPKHYHVKETGEVSRTSKDEDDFITVNSIKKEMVNYLTSPI 451

  Fly   257 VKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAG----ESESNLRKAFEEAEK 317
            :..| .|::.|..|.|||.:.:.:.||      :.....|..|.|.    ...|||    ::.:|
Yeast   452 IATP-AIILDGKQGIGKTRLLKELINE------VEKDHHIFVKYADCETLHETSNL----DKTQK 505

  Fly   318 -----------NSPAIIFIDEIDAIAPKRDKTHGEVERR------------IVSQLLTLMDGMKK 359
                       ..|::|.:|.::|:..|.....|:....            .::|:..:.:  |.
Yeast   506 LIMEWCSFCYWYGPSLIVLDNVEALFGKPQANDGDPSNNGQWDNASKLLNFFINQVTKIFN--KD 568

  Fly   360 SSHLIVMAATNRPNSIDPALRRFGRFDREI-----DIGIPDATGRLEVLR-IHTKN--MKLHDDV 416
            :..:.|:.:..:...|:|.|     ||:..     .:..||...|.::|. ..:||  |||:.|:
Yeast   569 NKRIRVLFSGKQKTQINPLL-----FDKHFVSETWSLRAPDKHARAKLLEYFFSKNQIMKLNRDL 628

  Fly   417 DLEQIAAESHGHVGADLASLCSEAALQQIREKM--DLIDLEDDKIDAEVLASLAVTMENFRYAMT 479
            ....::.|:.|....|         |:...||:  || .||.|       ....||.|.|..:::
Yeast   629 QFSDLSLETEGFSPLD---------LEIFTEKIFYDL-QLERD-------CDNVVTRELFSKSLS 676

  Fly   480 KSSPSALRET-VVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPG 543
            ..:|||||.. :.:..|..|.|||.|.:.|..|.|.:::|.::...|:...::...|:|.||.||
Yeast   677 AFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGILLYGYPG 741

  Fly   544 CGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKAR 608
            |||||||.|:|.:|..|||||||||:|..:.|.||.|:|::|::|:|..||:|||||.||||..|
Yeast   742 CGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDEFDSIAPKR 806

  Fly   609 GGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDK 673
            |   .|:.|..|||:||:||:|||......|:|:.||:|||:||.|:|||||||:.:...:|.:.
Yeast   807 G---HDSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRPGRLDKSVICNIPTES 868

  Fly   674 SREAILKA---------NLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEA-- 727
            .|..||:|         ..:|..|.|..||..||:.|.|||||||..:|..|...::.:.:.|
Yeast   869 ERLDILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKSVHRWLSAAD 933

  Fly   728 --------------EIRREKERAENQNSAMDMDEDDPVPEI---TSAHFE-----------EAMK 764
                          .|.....|.||:.....:.:.|.|.|.   |||..|           ||.:
Yeast   934 QSEVVPGNDNIEYFSINEHGRREENRLRLKTLLQQDVVHETKTSTSAASELTAVVTINDLLEACQ 998

  Fly   765 FARRSVSDNDIRKYEMFAQTLQQSRGFGQNFRFPGQTGNTSGSGNNLPVNS 815
            ..:.|:|.:::.|........|:.|           .|......|::.:.|
Yeast   999 ETKPSISTSELVKLRGIYDRFQKDR-----------NGEMPNGENSIDIGS 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	234/904 (26%)
		CDC48_N	47..129	CDD:280513	19/107 (18%)
		CDC48_2	153..213	CDD:215011	12/85 (14%)
		AAA	263..392	CDD:278434	29/160 (18%)
		AAA	536..669	CDD:278434	75/132 (57%)
		Vps4_C	<741..783	CDD:286426	12/55 (22%)
PEX1	NP_012724.1	PEX-1N	108..183	CDD:401267	2/20 (10%)
		SpoVK	457..929	CDD:223540	168/508 (33%)
		RecA-like_PEX1_r2	705..862	CDD:410934	81/159 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810