DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and AFG2

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_013501.1	Gene:	AFG2 / 851113	SGDID:	S000004389	Length:	780	Species:	Saccharomyces cerevisiae

Alignment Length:	736	Identity:	284/736 - (38%)
Similarity:	404/736 - (54%)	Gaps:	124/736 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DDNSVVSLSQAKMDELQLFRGDTVILKGKRRKETVCIVL---SDDTCPDEKIRMNRVVRNNLCVH 117
            ||:.|:...       .:|:.    ||.|...|::.:|:   |||:.||.         :.|.::
Yeast   153 DDSGVIMPG-------MIFQN----LKTKAGDESIDVVITDASDDSLPDV---------SQLDLN 197

  Fly   118 LSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRP 182
            :.|:.                        |...|||  ||.|.|:     ...|...|..:....
Yeast   198 MDDMY------------------------GGLDNLF--YLSPPFI-----FRKGSTHITFSKETQ 231

  Fly   183 IEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVELPLR 247
            ...|..|  |||                            :.|..:||..|::..:|..:|:||.
Yeast   232 ANRKYNL--PEP----------------------------LSYAAVGGLDKEIESLKSAIEIPLH 266

  Fly   248 HPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAF 312
            .|:||.:.||.||||||::||||||||::.|.|||.:.|....||||.|:||..||:|:.||..|
Yeast   267 QPTLFSSFGVSPPRGILLHGPPGTGKTMLLRVVANTSNAHVLTINGPSIVSKYLGETEAALRDIF 331

  Fly   313 EEAEKNSPAIIFIDEIDAIAPKR-DKTHGEVERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSID 376
            .||.|..|:||||||||:|||.| :...||||.|:|:.||||||||..:..::|:||||||||:|
Yeast   332 NEARKYQPSIIFIDEIDSIAPNRANDDSGEVESRVVATLLTLMDGMGAAGKVVVIAATNRPNSVD 396

  Fly   377 PALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMK----LHDDVDLEQIAAESHGHVGADLASLC 437
            |||||.||||:|::|||||...|.::|......|.    :.|...::.||:::||:|||||.:||
Yeast   397 PALRRPGRFDQEVEIGIPDVDARFDILTKQFSRMSSDRHVLDSEAIKYIASKTHGYVGADLTALC 461

  Fly   438 SEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIG 502
            .|:.::.|:..:. .|...||.      ||.||:::...||....|||:||..:|:|...|:|||
Yeast   462 RESVMKTIQRGLG-TDANIDKF------SLKVTLKDVESAMVDIRPSAMREIFLEMPKVYWSDIG 519

  Fly   503 GLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGP 567
            |.|.:|.:::|::|.|:|..:.|.:.|:...:|||.||||||.|||.|||:|.|...||::||||
Yeast   520 GQEELKTKMKEMIQLPLEASETFARLGISAPKGVLLYGPPGCSKTLTAKALATESGINFLAVKGP 584

  Fly   568 ELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDG 632
            |:...:.||||..:|:||.|||||||.::||||:|:::..|.|:   :..||:.|:..:|.|:||
Yeast   585 EIFNKYVGESERAIREIFRKARSAAPSIIFFDEIDALSPDRDGS---STSAANHVLTSLLNEIDG 646

  Fly   633 MGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANLRKSPLAKE-VDLTY 696
            :...|.|.|:.||||||.||.|:|||||||:.||:..||..:|..|||...:|....:. |||..
Yeast   647 VEELKGVVIVAATNRPDEIDAALLRPGRLDRHIYVGPPDVNARLEILKKCTKKFNTEESGVDLHE 711

  Fly   697 IAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMDMDEDDPVPEITSAHFEE 761
            :|..|:|:|||::..:||.|...||.:                    |:|    |.::...|||:
Yeast   712 LADRTEGYSGAEVVLLCQEAGLAAIME--------------------DLD----VAKVELRHFEK 752

  Fly   762 AMKFARRSVSDNDIRKYEMFA 782
            |.|...|.::...:..||.||
Yeast   753 AFKGIARGITPEMLSYYEEFA 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	284/736 (39%)
		CDC48_N	47..129	CDD:280513	16/75 (21%)
		CDC48_2	153..213	CDD:215011	12/59 (20%)
		AAA	263..392	CDD:278434	78/129 (60%)
		AAA	536..669	CDD:278434	72/132 (55%)
		Vps4_C	<741..783	CDD:286426	13/42 (31%)
AFG2	NP_013501.1	CDC48	51..773	CDD:273521	282/734 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810