Protein Alignment TER94 and VCP

DIOPT Version :10

• Sequence 1: NP_001097249.1
• Gene: TER94 / 36040
• FlyBaseID: FBgn0286784
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_009057.1
• Gene: VCP / 7415
• HGNCID: 12666
• Length: 806
• Species: Homo sapiens
• Alignment Length: 800
• Identity: 664/800 - (83%)
• Similarity: 736/800 - (92%)
• Gaps: 6/800 - (0%)

  Fly    30 KREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFRGDTVILKGKRRKETVCIVL 94
            |.:||:|||||:|:|||||||:||.|:|||||||||.|||||||||||||:||||:|:|.|||||
Human     8 KGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVL 72

  Fly    95 SDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIYLKP 159
            |||||.||||||||||||||.|.|.||:|:|.|||||||||:.:||||::.||:||||||:||||
Human    73 SDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKP 137

  Fly   160 YFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVG 224
            |||||||||..||.|:||..||.:|||||.|||.|||||||:|||.|:|:|||||:||||||.||
Human   138 YFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVG 202

  Fly   225 YDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFF 289
            |||||||||||||||||||||||||:||||||||||||||:||||||||||||||||||||||||
Human   203 YDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFF 267

  Fly   290 LINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLM 354
            |||||||||||||||||||||||||||||:||||||||:|||||||:||||||||||||||||||
Human   268 LINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLM 332

  Fly   355 DGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDVDLE 419
            ||:|:.:|:|||||||||||||||||||||||||:||||||||||||:|:||||||||.||||||
Human   333 DGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLE 397

  Fly   420 QIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPS 484
            |:|.|:|||||||||:||||||||.||:|||||||||:.|||||:.||||||::||:|:::|:||
Human   398 QVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPS 462

  Fly   485 ALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLL 549
            ||||||||||..||.||||||.||:|||||||||||||||||||||.||:|||||||||||||||
Human   463 ALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLL 527

  Fly   550 AKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGD 614
            ||||||||||||||:||||||||||||||||||:||||||.|||||||||||||||||||||:||
Human   528 AKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGD 592

  Fly   615 AGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAIL 679
            .||||||||||||||||||..||||||||||||||||||||||||||||||||||||:|||.|||
Human   593 GGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAIL 657

  Fly   680 KANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMD 744
            ||||||||:||:|||.::||:|.||||||||||||||||||||::||:|||||:||..|. |||:
Human   658 KANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNP-SAME 721

  Fly   745 MDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFGQNFRFP----GQTGNTS 805
            ::||||||||...||||||:|||||||||||||||||||||||||||| :||||    |..|.:.
Human   722 VEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFG-SFRFPSGNQGGAGPSQ 785

  Fly   806 GSGNNLPVNSPGDNGDDDLY 825
            |||.....:...::.|||||
Human   786 GSGGGTGGSVYTEDNDDDLY 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	631/739 (85%)
VCP	NP_009057.1	CDC48	25..764	CDD:273521	631/739 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727		11/19 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806		15/38 (39%)
		Interaction with UBXN6. /evidence=ECO:0000269|PubMed:18656546	797..806		4/8 (50%)
		PIM motif. /evidence=ECO:0000269|PubMed:24726327	802..806		3/3 (100%)