DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and Pex1

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001280735.1	Gene:	Pex1 / 71382	MGIID:	1918632	Length:	1284	Species:	Mus musculus

Alignment Length:	905	Identity:	232/905 - (25%)
Similarity:	401/905 - (44%)	Gaps:	162/905 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 HSEQDEKMKPKDSF---DKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDEL----Q 72
            ||.:.::.|.|...   ||.:.|:.:...::...||  .|||.  :..|:.:....::||    :
Mouse   338 HSPKQQQDKSKQGVLLPDKEKQLSKSPDHKQISSNR--SEEAA--EACVLKVVWNGLEELKNATE 398

  Fly    73 LFRGDTVILKGKRRKETVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVR 137
            ......::.:||       :.:.||......|.|:.|||         :..:::.|.:....:::
Mouse   399 FTESLELLHRGK-------VWIPDDLRKRLNIEMHAVVR---------ITPLETTPKIPRSLKLQ 447

  Fly   138 ---ILPIDESTEGVTGNLFEIYLK-------PYFLEAYRPIHM---------------------- 170
               .||.|.:.|.:. .:|..:::       |..:.....|.:
Mouse   448 PRENLPKDVNEETIK-TVFSSWVQQSATTMLPLVISKEERIKLEIKDGLREFSLSTVHSQEKEKE 511

  Fly   171 -GDNFIVRAA--MRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLN----AVGYDDI 228
             |....|.::  ::.|..:|:|                   :|:.:||:...::    ::....:
Mouse   512 EGKTVFVLSSILLQKISVQVLL-------------------EPMIKEEQSAEIDFLLPSLTLSSL 557

  Fly   229 GGCRKQLAQIKE-----MVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANET---- 284
            ||.....|...|     ::..||....:....|:: ...:|:.|..|:||:..|:|:..|.
Mouse   558 GGVSALGASAMEHITHSLLGRPLSRQLMALVAGLR-NGALLITGGKGSGKSTFAKAICKEAQDTL 621

  Fly   285 GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIA-----PKRDKTHGEVE- 343
            .|....::...:..|.....:..|..||.||....|::|.:|::|.||     |:::.:...|:
Mouse   622 DARVETVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSVPEQEHSPEAVQS 686

  Fly   344 RRIVSQLLTLMDGMKKSSHLIVMAATNR-PNSIDPAL---RRFGRFDREIDIGIPDATGRLEVLR 404
            :|:...|..::.....:..|:.:.||:: ..|:.|:|   :....|.....:..|:...|.|:|.
Mouse   687 QRLAHALNDMIKEFVSTGSLVALIATSQLQQSLHPSLVSAQGIHTFQCVQHLQPPNPEQRCEILH 751

  Fly   405 IHTKNMKL------HDDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEV 463
            ...|| ||      ..|:||:.||.::...|..|...|. :.|:.....:......||
Mouse   752 SVVKN-KLGCDISNFPDLDLQCIAKDTEAFVARDFTVLV-DRAIHSSLSRQHSSSRED------- 807

  Fly   464 LASLAVTMENFRYAMTKSSPSALRETVVEVP-NTTWTDIGGLESVKKELQELVQYPVEHPDKFLK 527
               |.:|..:|:.|:....|::||...:..| :..|..||||..|::.|.:.:|.|.::|:.|..
Mouse   808 ---LTLTTSDFQKALRGFLPASLRNVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFAN 869

  Fly   528 FGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAA 592
            ..::...|:|.|||||.||||||..:|.|...||||:||||||:.:.|.||..|||:|.:|::|.
Mouse   870 LPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIKGPELLSKYIGASEQAVRDVFIRAQAAK 934

  Fly   593 PCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILR 657
            ||:|||||.:|||..||   .|..|..|||:||:||::||:...:.|:::.||:|||:||||:||
Mouse   935 PCILFFDEFESIAPRRG---HDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLR 996

  Fly   658 PGRLDQLIYIPLPDDKSREAILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIR 722
            |||||:.:|.|.||..||..||....:...||.:|||.::|.||..|:||||..:...|...|::
Mouse   997 PGRLDKCVYCPPPDQVSRLEILTVLSKSLALADDVDLQHVASVTDSFTGADLKALLYNAQLEALQ 1061

  Fly   723 ------------QAIEAEIRREKERAENQNSAMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDI 775
                        .:.::::........|.:|..|....|     .....|:::.....|....|.
Mouse  1062 GRLLPSGLPDGGSSSDSDLSLSSMVFLNHSSGSDDSAGD-----GECGLEQSLLSLEMSEILPDE 1121

  Fly   776 RKYEMFAQTLQQSRGFGQNFRFPGQTGNTSGSG---------NNLPVNSPGDNGDDDLYS 826
            .|:.|:...      ||.::.  .:.||.:.|.         :::..:.|...|.|.|::
Mouse  1122 SKFNMYRLY------FGSSYE--SELGNGTPSDLSSHCLSAPSSVTQDLPAAPGKDPLFT 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	215/820 (26%)
		CDC48_N	47..129	CDD:280513	16/85 (19%)
		CDC48_2	153..213	CDD:215011	9/91 (10%)
		AAA	263..392	CDD:278434	32/142 (23%)
		AAA	536..669	CDD:278434	74/132 (56%)
		Vps4_C	<741..783	CDD:286426	8/41 (20%)
Pex1	NP_001280735.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..373		6/33 (18%)
		AAA	592..742	CDD:214640	32/150 (21%)
		AAA	596..725	CDD:278434	31/128 (24%)
		AAA	878..1010	CDD:214640	75/134 (56%)
		AAA	878..1007	CDD:278434	74/131 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1284
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810