DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and SPAST

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_055761.2	Gene:	SPAST / 6683	HGNCID:	11233	Length:	616	Species:	Homo sapiens

Alignment Length:	549	Identity:	148/549 - (26%)
Similarity:	237/549 - (43%)	Gaps:	132/549 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 AGESESNL---RKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVE-----RRIVSQLLT----- 352
            ||:.|..:   :|..||.||....|:               .|:.|     ||:.::::|
Human   139 AGQKEQAVEWYKKGIEELEKGIAVIV---------------TGQGEQCERARRLQAKMMTNLVMA 188

  Fly   353 -----LMDGMK------KSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIH 406
                 |::.|:      ||...:...:||       ...|.|....|.. .:|.....|    .|
Human   189 KDRLQLLEKMQPVLPFSKSQTDVYNDSTN-------LACRNGHLQSESG-AVPKRKDPL----TH 241

  Fly   407 TKNMKLHDDVDLEQIAAESHGHVGA-DLASLCSEAALQQ-------------------------- 444
            |.|........::..:|...||..| ..:.|...:.::|
Human   242 TSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTT 306

  Fly   445 -IREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVK 508
             .|:|.||                    :|||...:..:...:.|.|.......:.||.|.:..|
Human   307 ATRKKKDL--------------------KNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAK 351

  Fly   509 KELQELVQYPVEHPDKFLKFGMQ-PSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTM 572
            :.|||:|..|...|:.|.  |:: |:||:|.:||||.|||:||||:|.|..|.|.::....|.:.
Human   352 QALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSK 414

  Fly   573 WFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGM--GA 635
            :.||.|..||.:|..||...|.::|.||:||:...|.....|   |:.|:..:.|.|.||:  ..
Human   415 YVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD---ASRRLKTEFLIEFDGVQSAG 476

  Fly   636 KKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANLRK--SPLAKEVDLTYIA 698
            ...|.::||||||..:|.|:||  |..:.:|:.||::::|..:||..|.|  |||.:: :|..:|
Human   477 DDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLA 538

  Fly   699 KVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMDMDEDDPVPEITSAHFEEAM 763
            ::|.|:||:|||.:.:.|....||:.       :.|:.:|. ||.:|      ..|..:.|.|::
Human   539 RMTDGYSGSDLTALAKDAALGPIREL-------KPEQVKNM-SASEM------RNIRLSDFTESL 589

  Fly   764 KFARRSVSDNDIRKYEMFAQTLQQSRGFG 792
            |..:||||...:..|      ::.::.||
Human   590 KKIKRSVSPQTLEAY------IRWNKDFG 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	146/542 (27%)
		CDC48_N	47..129	CDD:280513
		CDC48_2	153..213	CDD:215011
		AAA	263..392	CDD:278434	23/114 (20%)
		AAA	536..669	CDD:278434	52/134 (39%)
		Vps4_C	<741..783	CDD:286426	12/41 (29%)
SPAST	NP_055761.2	Required for interaction with RTN1. /evidence=ECO:0000269\|PubMed:16602018	1..300		34/187 (18%)
		Required for midbody localization. /evidence=ECO:0000269\|PubMed:18997780	1..194		14/69 (20%)
		Required for interaction with ATL1. /evidence=ECO:0000269\|PubMed:16339213, ECO:0000269\|PubMed:16815977	1..80
		Required for nuclear localization. /evidence=ECO:0000269\|PubMed:15147984	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03021, ECO:0000269\|PubMed:15147984	4..11
		Required for interaction with SSNA1 and microtubules. /evidence=ECO:0000269\|PubMed:15269182	50..87
		Nuclear export signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03021, ECO:0000269\|PubMed:16026783	59..67
		Sufficient for interaction with CHMP1B. /evidence=ECO:0000269\|PubMed:18997780	112..196		15/71 (21%)
		Required for interaction with microtubules. /evidence=ECO:0000269\|PubMed:15269182	114..200		16/75 (21%)
		MIT_spastin	116..195	CDD:239142	14/70 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..266		9/46 (20%)
		Sufficient for microtubule severing. /evidence=ECO:0000269\|PubMed:15269182	228..616		126/438 (29%)
		Required for interaction with microtubules and microtubule severing. /evidence=ECO:0000269\|PubMed:15269182	270..328		9/77 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..312		2/33 (6%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03021, ECO:0000269\|PubMed:15147984	309..312		1/2 (50%)
		Required for interaction with microtubules. /evidence=ECO:0000269\|PubMed:23272056	310..312		0/1 (0%)
		RecA-like_spastin	343..506	CDD:410932	66/169 (39%)
		AAA_lid_3	533..587	CDD:407720	19/67 (28%)
		Vps4_C	<580..612	CDD:401324	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910