DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TER94 and FIGNL1

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001036227.1	Gene:	FIGNL1 / 63979	HGNCID:	13286	Length:	674	Species:	Homo sapiens

Alignment Length:	361	Identity:	120/361 - (33%)
Similarity:	179/361 - (49%)	Gaps:	45/361 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GKRVRILPIDESTEGVTGNLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCI 197
            ||.|..:|..:..|...|    :..|||......|.|            |::.::...:|:...:
Human   338 GKFVPPIPKQDGGEQNGG----MQCKPYGAGPTEPAH------------PVDERLKNLEPKMIEL 386

  Fly   198 VAPETVIFCDGDPIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVK-PPR 261
            :..|  |...|.|            |.::||.|.....|.|||:|..|:..|.:|  .|:: ||:
Human   387 IMNE--IMDHGPP------------VNWEDIAGVEFAKATIKEIVVWPMLRPDIF--TGLRGPPK 435

  Fly   262 GILMYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFID 326
            |||::||||||||||.:.:|:::||.||.|:...:.||..||.|..:|..|..|....||:||||
Human   436 GILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFID 500

  Fly   327 EIDAIAPKRDKTHGEVERRIVSQLLTLMDGMKKSS--HLIVMAATNRPNSIDPALRRFGRFDREI 389
            |||::..:|.....|..|||.::.|..:||...||  .::|:.|||||..||.|.||  |..:.:
Human   501 EIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRL 563

  Fly   390 DIGIPDATGRLE-VLRIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAALQQIR--EKMDL 451
            .|.:|:|:.|.: |:.:.:|......:.::|||..:|....|||:..||.||:|..||  :..|:
Human   564 YIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADI 628

  Fly   452 IDLEDDKIDAEVLASLAVTMEN-FRYAMTKSSPSAL 486
            ..:..|    :|.....:..|| ||......||..|
Human   629 ATITPD----QVRPIAYIDFENAFRTVRPSVSPKDL 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	120/361 (33%)
		CDC48_N	47..129	CDD:280513
		CDC48_2	153..213	CDD:215011	11/59 (19%)
		AAA	263..392	CDD:278434	57/130 (44%)
		AAA	536..669	CDD:278434
		Vps4_C	<741..783	CDD:286426
FIGNL1	NP_001036227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..179
		Necessary and sufficient for interaction with RAD51. /evidence=ECO:0000305\|PubMed:23754376	295..344		3/5 (60%)
		SpoVK	<374..668	CDD:223540	108/309 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910