DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and Spata5

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001156983.1	Gene:	Spata5 / 57815	MGIID:	1927170	Length:	893	Species:	Mus musculus

Alignment Length:	815	Identity:	301/815 - (36%)
Similarity:	453/815 - (55%)	Gaps:	118/815 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EQDEKMKPKDSFDKREDLATAILKRKD----------------RPNRLIVEEAQNDDNSVV---- 61
            |.|..:..||.....|:|...||::.|                |..:|.|.:.:..|.:.:
Mouse   142 EMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVLQVKGTDGTTLGKLQ 206

  Fly    62 ---------------SLSQAKMD-ELQLFRGDTVILKGKRRKETVCIVLSDDT---CPDEKIRMN 107
                           |:..:.:| ..||.:.|....:....:.|.|...:|.|   ..:..:.:.
Mouse   207 SASGTDAQGMASEHSSMESSDVDLSFQLSQLDLKEPQSPSSQSTPCKPTNDRTVNKAGEVLLDVT 271

  Fly   108 RVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIYLKPYFLEAYRPIHMG- 171
            :..|:...:.|.:...:: |            ..|.|.||.|..:.|..|       .:|...|
Mouse   272 QSPRDGSGLGLEESTGLK-C------------SFDSSKEGNTQPVSEEKL-------LKPASAGT 316

  Fly   172 ----DNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVGYDDIGGCR 232
                |.|...::...|..:.:.|:                      .:|::|...|.||.|||..
Mouse   317 KSNTDTFYFISSTTRINLRKICTN----------------------SKEQDSQFKVTYDMIGGLN 359

  Fly   233 KQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIM 297
            .||..|:|::||||:.|.|||:.|:..|||:|:|||||||||:||||||||.||:..:||||||:
Mouse   360 SQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424

  Fly   298 SKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLMDGM---KK 359
            ||..||:|:.||:.|.||....|:||||||:||:.|||:....|||:|:|:.|||||||:   ..
Mouse   425 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGS 489

  Fly   360 SSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVL-RIHTKNMKLHDDVDLEQIAA 423
            ...::|:.|||||.::|.||||.||||:||:||||:|..||::| ::..:...|....:|.::|.
Mouse   490 EGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLAN 554

  Fly   424 ESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPSALRE 488
            .:||:|||||.:||:||.|..:|.   ::..:.:..|::|...:.:|:.:|...|....|||:||
Mouse   555 NAHGYVGADLKALCNEAGLHALRR---VLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMRE 616

  Fly   489 TVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAI 553
            ..::|||.:|:||||||::|.:|::.|::|::||..|.:.|:||.:|||.||||||.||::|||:
Mouse   617 VAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKAL 681

  Fly   554 ANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGA 618
            |||...||:::|||||:..:.||||..||:||.|||:.||.::||||||::|..||.:.| ||..
Mouse   682 ANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSG-AGNV 745

  Fly   619 ADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANL 683
            ||||:.|:||||||:...|||.::.||||||.||.|::||||:|::||:||||..:|..||....
Mouse   746 ADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQF 810

  Fly   684 RKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMDMDED 748
            ...|::.||||..:...|..:|||::..:|:.|..||:.:.|:|:.
Mouse   811 HSMPISNEVDLDELVLQTDTYSGAEIIAVCKEAALLALEENIKADC------------------- 856

  Fly   749 DPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQ 783
                 |...||.:|:......:.::..|.||.:.:
Mouse   857 -----IMKRHFTQALSIVTPRIPESLRRFYEDYQE 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	291/769 (38%)
		CDC48_N	47..129	CDD:280513	15/104 (14%)
		CDC48_2	153..213	CDD:215011	8/64 (13%)
		AAA	263..392	CDD:278434	77/131 (59%)
		AAA	536..669	CDD:278434	78/132 (59%)
		Vps4_C	<741..783	CDD:286426	7/41 (17%)
Spata5	NP_001156983.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		CDC48_N	64..132	CDD:304500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..227		1/24 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..315		15/95 (16%)
		SpoVK	370..882	CDD:223540	249/539 (46%)
		AAA	390..522	CDD:278434	77/131 (59%)
		AAA	664..796	CDD:278434	78/132 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820