DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and nsfb

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001019625.2	Gene:	nsfb / 554200	ZFINID:	ZDB-GENE-050808-1	Length:	747	Species:	Danio rerio

Alignment Length:	726	Identity:	183/726 - (25%)
Similarity:	303/726 - (41%)	Gaps:	197/726 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 DELQLFRGDTVILKGKRRKETVCIVLSD-----------DTCPDEKIRMNRVVRNNLCVHLSDVV 122
            |||.|               |.|:|.|:           .|.|.:|.                |.
Zfish    14 DELSL---------------TNCVVASEKDFKSGQHLTIKTTPTQKF----------------VF 47

  Fly   123 SVQSCPDVKYGK-------------------RVRILPIDESTEGVTGNLFEI-YLK-------PY 160
            :|::.|.|..|.                   .|.:...|.|.:.|.....|| :|:       ||
Zfish    48 TVRTHPSVVPGTIAFSLPQRKWAGLSLNQDVEVSVYNFDPSRQYVGTMTIEIDFLQKKSIDSNPY 112

  Fly   161 --------FLEAY--RPIHMGDNFIVRAAMRPIEFKVVLTDPE---PYCIVAPET---------- 202
                    |::.:  :...|...|:.....:  .|.:|:.|.|   |..:...:.
Zfish   113 DSDKMAIEFIQCFTAQAFSMSQQFVFSFCDK--LFALVIKDIEAMDPSILRGEQNSSKKHKIDIG 175

  Fly   203 VIFCDGDPIKREEEEESLNAVGYD-------------------DIGGCRKQLAQI-KEMVELPLR 247
            ::..:...|..:.|..|:|.:|..                   .|||..|:.:.| :......:.
Zfish   176 LLHGNSQVIFEKAESSSVNLIGKAKTKGSRQSIINPDWNFERMGIGGLDKEFSDIFRRAFASRVF 240

  Fly   248 HPSLFKAIGVKPPRGILMYGPPGTGKTLIARAV-----ANETGAFFFLINGPEIMSKLAGESESN 307
            .|.:.:.:|.|..:|||:|||||.||||:||.:     |.|..    ::|||||::|..||||:|
Zfish   241 PPDIVEQMGCKHVKGILLYGPPGCGKTLMARQIGKMLNAREPK----VVNGPEILNKYVGESEAN 301

  Fly   308 LRKAFEEAEKNSPA--------IIFIDEIDAIAPKRDKTHGE--VERRIVSQLLTLMDGMKKSSH 362
            :||.|.:||:....        ||..||||||..:|....|.  |...:|:|||:.:||:::.::
Zfish   302 IRKLFADAEEEQKRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNN 366

  Fly   363 LIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMK----LHDDVDLEQIAA 423
            ::|:..||||:.||.||.|.||.:.:::||:||.|||:::|.|||..||    |..|||::::|.
Zfish   367 ILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDETGRVQILNIHTAKMKQSNMLAKDVDVKELAV 431

  Fly   424 ESHGHVGADLASLC----SEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMT----- 479
            |:..:.||:|..|.    |.|..:.|:....:      ::|.|...:|.|:..:|..::.
Zfish   432 ETKNYSGAELEGLVRAAQSTAMNRHIKATTQV------EVDTEKAQTLQVSRSDFLASLNNDIKP 490

  Fly   480 ------KSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLF 538
                  :...|.:...:|:..|.....:|..|.:.::.:...:.|:.              .||.
Zfish   491 AFGSNQEDYSSYIMNGIVKWSNAVSDILGDGELLVQQTKNSERTPLV--------------TVLL 541

  Fly   539 YGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESE--ANVRDIFDKA-RSAAPCVLFFDE 600
            .||...|||.||..||.:.|..||.:..|:.: :.|.|:.  ..::.||:.| :|...||: .|:
Zfish   542 EGPAHSGKTALAAKIAEQSQFPFIKICSPDKM-IGFTETAKCQAIKKIFEDAYKSQLSCVV-VDD 604

  Fly   601 LDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAK-----KNVFIIGATNRPDIIDPAILRPGR 660
            ::.:.        |......|..|.:|..:..:..|     :.:.|:|.|:|.|::.    ..|.
Zfish   605 IERLL--------DFVPIGPRFSNLVLQALLVLLKKPPPRGRKLLILGTTSRKDVLQ----EMGM 657

  Fly   661 LDQL---IYIP 668
            .|..   |:||
Zfish   658 SDSFSTTIHIP 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	183/726 (25%)
		CDC48_N	47..129	CDD:280513	13/70 (19%)
		CDC48_2	153..213	CDD:215011	14/90 (16%)
		AAA	263..392	CDD:278434	60/143 (42%)
		AAA	536..669	CDD:278434	39/144 (27%)
		Vps4_C	<741..783	CDD:286426
nsfb	NP_001019625.2	CDC48_N	5..85	CDD:308138	17/101 (17%)
		CDC48_2	111..183	CDD:215011	10/73 (14%)
		SpoVK	<220..490	CDD:223540	100/279 (36%)
		AAA	538..670	CDD:214640	39/145 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810