Protein Alignment TER94 and PEX1

DIOPT Version :10

• Sequence 1: NP_001097249.1
• Gene: TER94 / 36040
• FlyBaseID: FBgn0286784
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Alignment Length: 900
• Identity: 245/900 - (27%)
• Similarity: 401/900 - (44%)
• Gaps: 161/900 - (17%)

  Fly    22 MKPKDSFDKREDLATAILKRKDRPNRLIVEEAQNDDNS------VVSLSQAKMDEL----QLFRG 76
            :.||....|.:....:..|.|.....|..::.::|.|.      |:.:....::||    :..:.
Human   339 LSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKN 403

  Fly    77 DTVILKGKRRKETVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVR---I 138
            ..|:..||       :.:.||......|.|:.|||         :..|:..|.:....:::   .
Human   404 VEVLHLGK-------VWIPDDLRKRLNIEMHAVVR---------ITPVEVTPKIPRSLKLQPREN 452

  Fly   139 LPIDESTEGVTGNLFEIYLK-------PYFL--EAYRPIHMGDNF------IVRAAMRPIEFKVV 188
            ||.|.|.|.:. .:|..:|:       |..:  |.:..:...|..      ||.:..:..:..:.
Human   453 LPKDISEEDIK-TVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIF 516

  Fly   189 LTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAV----------GYDDIGGCRKQLAQIKEMVE 243
            |..|.    :..:|.|....||:.:||..|.::.:          |.:.:|     ::.::.:..
Human   517 LLSPN----LLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLG-----VSSLEHITH 572

  Fly   244 LPLRHP---SLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIM--SKLAGE 303
            ..|..|   .|...:.......:|:.|..|:||:.:|:|:..|  ||..|....|.:  ..|.|:
Human   573 SLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKE--AFDKLDAHVERVDCKALRGK 635

  Fly   304 SESNLRK----AFEEAEKNSPAIIFIDEIDAIA-----PKRDKTHGEVE-RRIVSQLLTLMDGMK 358
            ...|::|    ||.||....|:::.:|::|.||     |:.:.:...|: :|:...|..::....
Human   636 RLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFI 700

  Fly   359 KSSHLIVMAATNR-PNSIDPAL---RRFGRFDREIDIGIPDATGRLEVLRIHTKN-----MKLHD 414
            ....|:.:.||:: ..|:.|.|   :....|.....|..|:...|.|:|....||     :....
Human   701 SMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFT 765

  Fly   415 DVDLEQIAAESHGHVGADLASLCSEAALQQI-------REKMDLIDLEDDKIDAEVLASLAVTME 472
            |:||:.:|.|:.|.|..|...|...|...::       |||                  |.:|..
Human   766 DLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREK------------------LVLTTL 812

  Fly   473 NFRYAMTKSSPSALRETVVEVP-NTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGV 536
            :|:.|:....|::||...:..| :..|..||||..|::.|.:.:|.|.::|:.|....::...|:
Human   813 DFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGI 877

  Fly   537 LFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDEL 601
            |.|||||.||||||..||.|.:.|||||||||||:.:.|.||..|||||.:|::|.||:|||||.
Human   878 LLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEF 942

  Fly   602 DSIAKARGGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIY 666
            :|||..||   .|..|..|||:||:||::||:...:.|:::.||:|||:||||:|||||||:.:|
Human   943 ESIAPRRG---HDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVY 1004

  Fly   667 IPLPDDKSREAILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIR-QAIEAEIR 730
            .|.||..||..||.......|||.:|||.::|.||..|:||||..:...|...|:. ..:.:.::
Human  1005 CPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQ 1069

  Fly   731 REKERAENQNSAMDM-------DEDDPVPE--------ITSAHFEEAMKFARRSVSDNDIRKYEM 780
            .....:::..|...|       ..||...:        :.|....|.:.         |..|:.|
Human  1070 DGSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILP---------DESKFNM 1125

  Fly   781 FAQTLQQSRGFGQNFRFPGQTGNTSGSG---------NNLPVNSPGDNGDDDLYS 826
            :...      ||.::.  .:.||.:.|.         :::..:.||..|.|.|:|
Human  1126 YRLY------FGSSYE--SELGNGTSSDLSSQCLSAPSSMTQDLPGVPGKDQLFS 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	229/825 (28%)
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367		4/20 (20%)
		CDC48	<595..1065	CDD:273521	176/492 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283