DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and Spast

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001156342.1	Gene:	Spast / 50850	MGIID:	1858896	Length:	614	Species:	Mus musculus

Alignment Length:	553	Identity:	147/553 - (26%)
Similarity:	232/553 - (41%)	Gaps:	140/553 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 AGESESNL---RKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVE-----RRIVSQLLTLMDGM 357
            ||:.|..:   :|..||.||....|:               .|:.|     ||:.::::|.:...
Mouse   137 AGQKEQAVEWYKKGIEELEKGIAVIV---------------TGQGEQYERARRLQAKMMTNLVMA 186

  Fly   358 KKSSHLIVMAATNRPNSIDPALR-----------------RFGRFDREIDIGIPDATGRLEVLRI 405
            |....|:        ..:.|.|:                 |.|....|.. .:|.....|    .
Mouse   187 KDRLQLL--------EKLQPVLQFSKSQTDVYNESTNLTCRNGHLQSESG-AVPKRKDPL----T 238

  Fly   406 HTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAAL---------------------------- 442
            |..|........|:..:|...||   ..|..||..::
Mouse   239 HASNSLPRSKTVLKSGSAGLSGH---HRAPSCSGLSMVSGARPGPGPAATTHKGTPKPNRTNKPS 300

  Fly   443 ---QQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGL 504
               ..:|:|.||                    :|||...:..:...:.|.|.......:.||.|.
Mouse   301 TPTTAVRKKKDL--------------------KNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQ 345

  Fly   505 ESVKKELQELVQYPVEHPDKFLKFGMQ-PSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPE 568
            |..|:.|||:|..|...|:.|.  |:: |:||:|.:||||.|||:||||:|.|..|.|.::....
Mouse   346 ELAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAAS 408

  Fly   569 LLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGM 633
            |.:.:.||.|..||.:|..||...|.::|.||:||:...|.....|   |:.|:..:.|.|.||:
Mouse   409 LTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD---ASRRLKTEFLIEFDGV 470

  Fly   634 --GAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANLRK--SPLAKEVDL 694
              .....|.::||||||..:|.|:||  |..:.:|:.||::::|..:||..|.|  |||.:: :|
Mouse   471 QSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-EL 532

  Fly   695 TYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMDMDEDDPVPEITSAHF 759
            ..:|::|.|:||:|||.:.:.|....||:.       :.|:.:|. ||.:|      ..|..:.|
Mouse   533 AQLARMTDGYSGSDLTALAKDAALGPIREL-------KPEQVKNM-SASEM------RNIRLSDF 583

  Fly   760 EEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFG 792
            .|::|..:||||...:..|      ::.::.||
Mouse   584 TESLKKIKRSVSPQTLEAY------IRWNKDFG 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	145/546 (27%)
		CDC48_N	47..129	CDD:280513
		CDC48_2	153..213	CDD:215011
		AAA	263..392	CDD:278434	21/115 (18%)
		AAA	536..669	CDD:278434	52/134 (39%)
		Vps4_C	<741..783	CDD:286426	12/41 (29%)
Spast	NP_001156342.1	Required for interaction with RTN1. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	1..298		32/191 (17%)
		Required for midbody localization. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	1..192		15/69 (22%)
		Required for interaction with ATL1. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	1..48
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03021	4..11
		Required for interaction with SSNA1 and microtubules. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	48..85
		Nuclear export signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03021	57..65
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..112
		Sufficient for interaction with CHMP1B. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	110..194		16/79 (20%)
		Required for interaction with microtubules. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	112..198		16/83 (19%)
		MIT_spastin	114..193	CDD:239142	15/70 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..306		13/93 (14%)
		Sufficient for microtubule severing. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	226..614		127/441 (29%)
		Required for interaction with microtubules and microtubule severing. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	268..326		8/77 (10%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03021	307..310		1/2 (50%)
		Required for interaction with microtubules. /evidence=ECO:0000250\|UniProtKB:Q9UBP0	308..310		0/1 (0%)
		P-loop_NTPase	339..>395	CDD:304359	28/57 (49%)
		AAA	372..508	CDD:214640	56/140 (40%)
		AAA	376..506	CDD:278434	52/134 (39%)
		Vps4_C	<578..610	CDD:286426	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810