DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and vcp

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001005677.1	Gene:	vcp / 448177	XenbaseID:	XB-GENE-969573	Length:	805	Species:	Xenopus tropicalis

Alignment Length:	809	Identity:	664/809 - (82%)
Similarity:	735/809 - (90%)	Gaps:	19/809 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SFDKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFRGDTVILKGKRRKETVC 91
            |..|.:||:|||||:|.|||||||:|:.|:|||||||||||||||||||||||:||||:|:|.||
Frog     5 SDSKSDDLSTAILKQKSRPNRLIVDESINEDNSVVSLSQAKMDELQLFRGDTVLLKGKKRREAVC 69

  Fly    92 IVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIY 156
            ||||||||.||||||||||||||.|.|.||:|:|.|||||||||:.:||||::.||:||||||:|
Frog    70 IVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVY 134

  Fly   157 LKPYFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLN 221
            ||||||||||||..||.|:||..||.:|||||.|||.|||||||:|||.|:|:|||||:||||||
Frog   135 LKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN 199

  Fly   222 AVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGA 286
            .|||||||||||||||||||||||||||:||||||||||||||:|||||||||||||||||||||
Frog   200 EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGA 264

  Fly   287 FFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLL 351
            ||||||||||||||||||||||||||||||||:||||||||:|||||||:|||||||||||||||
Frog   265 FFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLL 329

  Fly   352 TLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDV 416
            |||||:|:.:|:|||||||||||||||||||||||||:||||||:|||||:|:||||||||.|||
Frog   330 TLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDSTGRLEILQIHTKNMKLSDDV 394

  Fly   417 DLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKS 481
            ||||:|.|:|||||||||:||||||||.||:|||||||||:.|||||:.||||||::||:|:::|
Frog   395 DLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQS 459

  Fly   482 SPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGK 546
            :||||||||||||..||.||||||.||:|||||||||||||||||||||.||:||||||||||||
Frog   460 NPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGK 524

  Fly   547 TLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGN 611
            |||||||||||||||||:||||||||||||||||||:||||||.|||||||||||||||||||||
Frog   525 TLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGN 589

  Fly   612 VGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSRE 676
            :||.||||||||||||||||||..||||||||||||||||||||||||||||||||||||:|||.
Frog   590 IGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRI 654

  Fly   677 AILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNS 741
            |||||||||||:||:|||.::||:|.||||||||||||||||||||::||.|||||:||..|. |
Frog   655 AILKANLRKSPVAKDVDLDFLAKMTNGFSGADLTEICQRACKLAIRESIENEIRRERERQTNP-S 718

  Fly   742 AMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFGQNFRFP----GQTG 802
            ||:::||||||||...||||||:|||||||||||||||||||||||||||| :||||    |..|
Frog   719 AMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFG-SFRFPAGGQGGAG 782

  Fly   803 NTSGSGNNLPVNSPGDNG------DDDLY 825
            .:.|:|.       |..|      :||||
Frog   783 PSQGAGG-------GSGGSHFNEEEDDLY 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	630/739 (85%)
		CDC48_N	47..129	CDD:280513	66/81 (81%)
		CDC48_2	153..213	CDD:215011	44/59 (75%)
		AAA	263..392	CDD:278434	118/128 (92%)
		AAA	536..669	CDD:278434	125/132 (95%)
		Vps4_C	<741..783	CDD:286426	34/41 (83%)
vcp	NP_001005677.1	CDC48	25..764	CDD:273521	630/739 (85%)
vcp	NP_001005677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..805		16/45 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1899
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5168
Inparanoid	1	1.050	1329	1.000	Inparanoid score	I148
OMA	1	1.010	-	-		QHG60945
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		oto104632
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1760
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080