DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and nvl

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_998649.1	Gene:	nvl / 406805	ZFINID:	ZDB-GENE-040426-2871	Length:	796	Species:	Danio rerio

Alignment Length:	615	Identity:	264/615 - (42%)
Similarity:	381/615 - (61%)	Gaps:	59/615 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 GDPIKREEE---EESLNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPP 269
            |.|.|:.:.   |...::|.::|.||..:.|.::.::: :.:|||.:::.:||.||||.|::|||
Zfish   206 GVPAKKSKVKGFELQFSSVKFEDFGGSDETLEEVCKLL-IHMRHPEVYQRLGVVPPRGFLLHGPP 269

  Fly   270 GTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPK 334
            |.||||:|:|||.||......|:.||::|.::||||..||:.||:|..::|.|:||||||||.||
Zfish   270 GCGKTLLAQAVAGETALPLLKISAPELVSGVSGESEQKLRELFEQAISSAPCILFIDEIDAITPK 334

  Fly   335 RDKTHGEVERRIVSQLLTLMD---GMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDA 396
            |:....::|||||:||||.||   .|.:.:.::|:.|||||:|:||||||.|||||||.:||||.
Zfish   335 RETASKDMERRIVAQLLTCMDDLNSMLEPAQVLVIGATNRPDSLDPALRRAGRFDREICLGIPDE 399

  Fly   397 TGRLEVLRIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAALQQIR--------------- 446
            ..|:::|:...:.::|.||.|...:|..:.|:|||||.:||.|||:..:.
Zfish   400 GARMKILKTLCRKIRLPDDFDFRHLARLTPGYVGADLMALCREAAMNAVNRILLEPTTEDQITPT 464

  Fly   447 ----EKMDL----IDLEDDKIDAEVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGG 503
                ..:||    :.|.:|:     ||:|.|.|.:|..::.:..|||.||....||:.||.|:|.
Zfish   465 LALARLLDLLKSSVSLSEDQ-----LAALCVLMSDFSSSLVRVQPSAKREGFATVPDVTWADVGA 524

  Fly   504 LESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPE 568
            |:.|::||...:..|:::|::|...|:....|:|..|||||||||||||:||....|||||||||
Zfish   525 LQDVREELHMAIMAPIQNPEQFKALGLSAPAGLLLAGPPGCGKTLLAKAVANASGLNFISVKGPE 589

  Fly   569 LLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGM 633
            ||.|:.||||..||.:|.:.|::||||:||||:|::...|..:   ..||:.||:||:|||||||
Zfish   590 LLNMYVGESERAVRQVFQRGRNSAPCVIFFDEIDALCPRRSEH---ESGASVRVVNQLLTEMDGM 651

  Fly   634 GAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANLR---KSPLAKEVDLT 695
            ..::.|||:.|||||||||||:|||||||:.:|:.||....|.|||....:   |..|..:|.|.
Zfish   652 ENRRQVFIMAATNRPDIIDPAVLRPGRLDKTLYVGLPPAADRHAILNTITKGGTKPQLDSDVSLE 716

  Fly   696 YIAKVT--QGFSGADLTEICQRACKLAIRQAIE-AEIRREKERAENQNSAMDMDEDDPVPEITSA 757
            .||...  :.|:||||:.:.:.||..|:|..:: |:...|        ||.|:       .::..
Zfish   717 EIAHDARCETFTGADLSALVREACVNALRVHLDPAQTHTE--------SAKDI-------RVSRV 766

  Fly   758 HFEEAMKFARRSVSDNDIRKYEMFAQTLQQ 787
            |||:|.|..|.|||..|...||...:||.:
Zfish   767 HFEDAFKKVRPSVSKKDQLMYERLRETLSR 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	264/613 (43%)
		CDC48_N	47..129	CDD:280513
		CDC48_2	153..213	CDD:215011	2/4 (50%)
		AAA	263..392	CDD:278434	73/131 (56%)
		AAA	536..669	CDD:278434	81/132 (61%)
		Vps4_C	<741..783	CDD:286426	15/41 (37%)
nvl	NP_998649.1	Nucleolin_bd	2..71	CDD:293330
		RNA_polI_A34	<165..215	CDD:285426	3/8 (38%)
		SpoVK	246..792	CDD:223540	253/568 (45%)
		AAA	264..395	CDD:278434	73/130 (56%)
		P-loop_NTPase	537..>573	CDD:304359	17/35 (49%)
		AAA	557..687	CDD:278434	81/132 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820