Protein Alignment TER94 and spast

DIOPT Version :10

• Sequence 1: NP_001097249.1
• Gene: TER94 / 36040
• FlyBaseID: FBgn0286784
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_998080.2
• Gene: spast / 405851
• ZFINID: ZDB-GENE-040426-2331
• Length: 570
• Species: Danio rerio
• Alignment Length: 567
• Identity: 156/567 - (27%)
• Similarity: 258/567 - (45%)
• Gaps: 93/567 - (16%)

  Fly   267 GPPGTGKTLIARAVAN-ETGAFFFLINGPEIMSKLAGESESNL---RKAFEEAEKNSPAIIFIDE 327
            ||.|:.:|  ...:.| ...||.|:....:|.....|:.:..:   ||...|.||....     :
Zfish    69 GPDGSEET--GERIRNYHKQAFEFISVALQIDEDEKGDKQKAVQWYRKGIAELEKGIQI-----Q 126

  Fly   328 IDAIAPKRDKTHGEVERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIG 392
            :.....|.|:.. :::.::::.|....|.:|...:|:..:...  :|.|.:...|
Zfish   127 VTGAGEKADRAR-KLQDKMITNLSMAEDRLKLLGNLLSQSPAE--SSSDDSFYSF---------- 178

  Fly   393 IPDATGRLEVLRIHTKNMKLHDDVDL---EQIAAESHGHVGADLASL-CSEAALQQIR------E 447
               :.|.|..........|..|.:.:   ..:..::......:.:.| |:.:|.|..|      :
Zfish   179 ---SNGNLRPAPASGAVSKKKDTLTITNQTSLRPKNPPKSTPNASGLNCTPSAAQSSRTGPQNNQ 240

  Fly   448 KMDLIDLEDDKIDAEVLASLAVT--------MENFRYAMTKSSPSALRETVVEVPNTTWTDIGGL 504
            |...:     |....|.||...|        |:||:...:|.:...|.|.|.......:.||.|.
Zfish   241 KGPTV-----KGKNNVKASTTATASPQRKRDMKNFKNVDSKLASLILNEIVDSGSVVRFDDIAGQ 300

  Fly   505 ESVKKELQELVQYPVEHPDKFLKFGMQ-PSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPE 568
            :..|:.|||:|..|...|:.|.  |:: |:||:|.:||||.|||:||||:|.|..|.|.::....
Zfish   301 DLAKQALQEIVILPALRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAMESNATFFNISAAT 363

  Fly   569 LLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGM 633
            |.:.:.||.|..||.:|..||...|.::|.||:||:...|.....|   |:.|:..:.|.|.||:
Zfish   364 LTSKYVGEGEKLVRALFAVARELQPSIIFIDEIDSLLCERREGEHD---ASRRLKTEFLIEFDGV 425

  Fly   634 --GAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANLRK--SPLAKEVDL 694
              |..:.|.::||||||..:|.|:||  |..:.||:.||.:::|..:||..|.|  :||::: :|
Zfish   426 QSGGDERVLVMGATNRPQELDEAVLR--RFAKRIYVALPTEETRLKLLKNLLSKHRNPLSQK-EL 487

  Fly   695 TYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMDMDEDDPVPEITSAHF 759
            :.:|::|.|:||:|||.:.:.|....||     |::.|:.|..:.:...|:...|         |
Zfish   488 SQLARLTDGYSGSDLTSLAKDAALGPIR-----ELKPEQVRNMSAHEMRDIRISD---------F 538

  Fly   760 EEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFGQNFRFPGQTGNTSG 806
            .|::|..:||||          .|||.      |..|:..:.|:|:|
Zfish   539 LESLKRIKRSVS----------PQTLD------QYVRWNREYGDTTG 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	151/546 (28%)
spast	NP_998080.2	MIT_spastin	80..158	CDD:239142	16/83 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..269		14/87 (16%)
		RecA-like_spastin	296..459	CDD:410932	68/169 (40%)
		AAA_lid_3	486..534	CDD:465537	16/52 (31%)
		Vps4_C	<532..565	CDD:462762	14/57 (25%)