DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and IQCA1L

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001291348.1	Gene:	IQCA1L / 392843	HGNCID:	22831	Length:	818	Species:	Homo sapiens

Alignment Length:	858	Identity:	169/858 - (19%)
Similarity:	318/858 - (37%)	Gaps:	246/858 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QDEKMKPKDSFDKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQ--AKMDELQLFRGDTVI 80
            ||.|:.|       .||...|      |...::|::.......:.|::  ::::.:...:..|
Human   107 QDFKLTP-------ADLEVPI------PKYFLLEQSTTVRERGLILAEILSRLEPVSSQKSFT-- 156

  Fly    81 LKGKRRKETVCIVLSDDTCPDEKIRMN--RVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDE 143
              |..|.|.:.:|...:.....::|..  |.:|.                |.:...|:|.....:
Human   157 --GMHRTEAIILVQKAERARQGRLRATFMREIRR----------------DEEQDGRIREDGWHK 203

  Fly   144 STEGVTG----NLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRP----IEFKVVLTDPEPYCIVAP 200
            .::|...    .:::.||:....:..|.:.|  .||   .|.|    :|...:::.|   |:|.
Human   204 FSQGQAAVTIQKVWKGYLQRKRTQQDRRMEM--EFI---GMLPSPNQVEHLSIISQP---CLVE- 259

  Fly   201 ETVIFCDGDPIKREEEEESLNAV---GYDDI----GGCRKQLAQIKEMV--------ELPLRHPS 250
                  |...:::.|:||...|.   .:|.:    |...|:  ::||.:        :|..|.|.
Human   260 ------DVQRLRQMEKEEEFRAAMVKAHDSLVETEGPDMKE--KMKEQIRQWFIECHDLTGRFPD 316

  Fly   251 LFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAF-FFLINGPE-IMSKLAGESESNLRKAFE 313
                           |....:|            |:: .|....|| :..:|..:.:.|.:|..|
Human   317 ---------------YPDASSG------------GSYSIFADKTPEQVRMELEMQMQENRKKEQE 354

  Fly   314 EAEKNSPAIIFIDEIDAIAPKRDKT-HGEVERRIVSQLLTLMDGMKKSSHLIVMAAT-------- 369
            ::::...     ||.:....|.:|. .|||:  .|.|:|        .|..|.|...
Human   355 KSKEKGK-----DEKEKKKGKEEKAKKGEVD--AVLQVL--------PSKCIPMICAGHEEYLNT 404

  Fly   370 --NRPNSIDPA-------LRRFGRFDREIDIGIP-DATGRLEVLRIHTKNMKLHDDVDLEQIAAE 424
              ||..||.|:       ||...|.:.|::|.|. |     |::|...:.::|..|.:.|:....
Human   405 WKNRCESIHPSQNYDSETLREEKRKEVELEIRIQVD-----ELMRQELRKLRLAVDKEEERPLRA 464

  Fly   425 SHGHVGADLA-----SLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPS 484
            .....|....     .|.|:.:::.:.|::             |::.|          :.||...
Human   465 PKKTPGKKTGKKKEKDLTSDRSVESLYEEL-------------VISGL----------LRKSESV 506

  Fly   485 ALRETVVEVPNTTWTDIGGLESVKKEL---------QELVQYPVEHPDKFLKFG------MQP-S 533
            ||::.:.:     :..:|...|:.|:|         |.:..|.|      |:.|      |.| .
Human   507 ALKDYIGD-----FLYLGSTLSLVKKLPMPSLFDIRQNVALYAV------LRLGSPDIHIMAPLI 560

  Fly   534 RGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEAN--VRDIFDKARSAAPCVL 596
            |.:|..||.|.||.:|.||:..|..||...:....||..:.|.:.|.  |..:|..||...|.|:
Human   561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMMVHIVFKVARLLQPSVI 625

  Fly   597 FFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAKKN-------------VFIIGATNRP 648
            :              :|:|.....:...:...|||....||:             |.:||.|:||
Human   626 W--------------IGNAEKNFYKKTPKEDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRP 676

  Fly   649 DIID-PAILRPGRLDQLIYIPLPDDKSREAILKANLRKSPL--AKEVDLTYIAKVTQGFSGADLT 710
            .:.: ..:.|.  .::::::|.||..||..:.|..:....:  .:.:|::.:|||:.|::...:.
Human   677 QLAEMRGLCRV--YERILFMPRPDYASRYVLWKRMIEARGIQPTQHLDISALAKVSDGYTPGHIL 739

  Fly   711 EICQ------RACKLAIRQAIEAE-----IRREKERAENQNSAMDMDEDDPVPEITSAHFEEAMK 764
            :..|      |..:|:.|..:.:|     ::.:....|.:.|..|.....|:.:.:..|..:.::
Human   740 QAIQSVLSERRFLQLSKRPLVASEFLGQLVKLDPVYREEEESLKDWYFKTPLGKKSMKHRMDQLE 804

  Fly   765 FARRSVSDNDIRK 777
             |..:..|.:.:|
Human   805 -AEEAKLDKEKKK 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	161/829 (19%)
		CDC48_N	47..129	CDD:280513	10/85 (12%)
		CDC48_2	153..213	CDD:215011	13/63 (21%)
		AAA	263..392	CDD:278434	32/148 (22%)
		AAA	536..669	CDD:278434	36/148 (24%)
		Vps4_C	<741..783	CDD:286426	7/37 (19%)
IQCA1L	NP_001291348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..482		2/23 (9%)
		SpoVK	<561..734	CDD:223540	48/188 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..818		4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900