DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and Spata5

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_008759154.1	Gene:	Spata5 / 361935	RGDID:	1310478	Length:	893	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	301/822 - (36%)
Similarity:	453/822 - (55%)	Gaps:	132/822 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EQDEKMKPKDSFDKREDLATAILKRKD----------------RPNRLIVEEAQNDDNSVV---- 61
            |.|..:..||.....|:|...||::.|                |..:|.|.:.:..|.:.:
  Rat   142 EMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVLQVKGTDGTTLGKPQ 206

  Fly    62 ---------------SLSQAKMD-ELQLFRGDTVILKGKRRKETVCIVLSDDTCPDEKIRMNRV- 109
                           |:..:.:| ..||.:.|....:....:.|.|..::|.|       ||:.
  Rat   207 SSSGTDVHGMASEQSSMESSDVDISFQLSQLDLKEPQSPASQSTPCKPINDRT-------MNKAG 264

  Fly   110 ---------VRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIYLKPYFLEAY 165
                     .|:...:.|.::..:: |            ..|.|.||.|..:.|..|       .
  Rat   265 EVLLDVTQSPRDGSGLGLEEITGLK-C------------SFDSSKEGNTQPISEEKL-------L 309

  Fly   166 RPIHMG-----DNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVGY 225
            :....|     |.|...::...|..:.:.|:                      .:|::|...|.|
  Rat   310 KSTSAGAKNNTDTFYFISSTTRINLRKICTN----------------------SKEQDSQFKVTY 352

  Fly   226 DDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFL 290
            |.|||...||..|:|::||||:.|.|||:.|:..|||:|:|||||||||:||||||||.||:..:
  Rat   353 DMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSV 417

  Fly   291 INGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLMD 355
            ||||||:||..||:|:.||:.|.||....|:||||||:||:.|||:....|||:|:|:.||||||
  Rat   418 INGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMD 482

  Fly   356 GM---KKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVL-RIHTKNMKLHDDV 416
            |:   .....::|:.|||||.::|.||||.||||:||:||||:|..||::| ::..:...|....
  Rat   483 GIGSEGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKA 547

  Fly   417 DLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKS 481
            :|.::|..:||:|||||.:||:||.|..:|.   ::..:.:..|::|...:.:|:.:|...|...
  Rat   548 ELLRLANNAHGYVGADLKALCNEAGLYALRR---VLRKQPNLPDSKVAGMVKITLNDFLQGMNDI 609

  Fly   482 SPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGK 546
            .|||:||..::|||.:|:||||||::|.:|::.|::|::||..|.:.|:||.:|||.||||||.|
  Rat   610 RPSAMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFSRMGIQPPKGVLLYGPPGCSK 674

  Fly   547 TLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGN 611
            |::|||:|||...||:::|||||:..:.||||..||::|.|||:.||.::||||||::|..||.:
  Rat   675 TMIAKALANESGLNFLAIKGPELMNKYVGESERAVREVFRKARAVAPSIIFFDELDALAVERGSS 739

  Fly   612 VGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSRE 676
            .| ||..||||:.|:||||||:...|||.::.||||||.||.|::||||:|::||:||||..:|.
  Rat   740 SG-AGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRR 803

  Fly   677 AILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNS 741
            .||.......|::.||||..:...|..:|||::..:|:.|..||:.:.|:|:.
  Rat   804 EILNLQFHSMPISNEVDLDELVLQTDTYSGAEIIAVCKEAALLALEENIKADC------------ 856

  Fly   742 AMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQ 783
                        |...||.:|:......:.::..|.||.:.:
  Rat   857 ------------IMKRHFTQALSIVTPRIPESLRRFYEDYQE 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	291/776 (38%)
		CDC48_N	47..129	CDD:280513	17/111 (15%)
		CDC48_2	153..213	CDD:215011	7/64 (11%)
		AAA	263..392	CDD:278434	77/131 (59%)
		AAA	536..669	CDD:278434	77/132 (58%)
		Vps4_C	<741..783	CDD:286426	7/41 (17%)
Spata5	XP_008759154.1	CDC48_N	64..132	CDD:304500
		SpoVK	370..882	CDD:223540	248/539 (46%)
		AAA	390..522	CDD:278434	77/131 (59%)
		AAA	664..796	CDD:278434	77/132 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820