DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and cdc48

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_593287.2	Gene:	cdc48 / 2542744	PomBaseID:	SPAC1565.08	Length:	815	Species:	Schizosaccharomyces pombe

Alignment Length:	803	Identity:	554/803 - (68%)
Similarity:	676/803 - (84%)	Gaps:	10/803 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PKDSFDKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFRGDTVILKGKRRKE 88
            |||:: ..||.|||||::|.:||.|:|::|.||||||::||...|:.|||||||||::||||||:
pombe    23 PKDTY-SAEDTATAILRKKRKPNSLVVDDATNDDNSVITLSSNTMETLQLFRGDTVVVKGKRRKD 86

  Fly    89 TVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLF 153
            ||.|||:|:...|...|:||||||||.|.|.|:|::..|||:||.:|:.:||:.::.||:||:||
pombe    87 TVLIVLTDEEMEDGVARINRVVRNNLRVRLGDIVTINPCPDIKYAERISVLPLADTVEGLTGSLF 151

  Fly   154 EIYLKPYFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEE 218
            ::||||||:||||||..||.|:||.:||.:|||||...|:.:.||:.:|:|..:|:||.||:||.
pombe   152 DVYLKPYFVEAYRPIRKGDLFVVRGSMRQVEFKVVDVAPDEFGIVSQDTIIHWEGEPINREDEES 216

  Fly   219 SLNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANE 283
            ||..||||||||||:|:|||:|:||||||||.|||:||:||||||||||||||||||:|||||||
pombe   217 SLAEVGYDDIGGCRRQMAQIRELVELPLRHPQLFKSIGIKPPRGILMYGPPGTGKTLMARAVANE 281

  Fly   284 TGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVS 348
            ||||||||||||||||:|||||||||||||||||||||||||||||:|||||:||:||||||:||
pombe   282 TGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVS 346

  Fly   349 QLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLH 413
            ||||||||||..|:::||||||||||||||||||||||||:|:||||.|||||:||||||||||.
pombe   347 QLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDVGIPDPTGRLEILRIHTKNMKLA 411

  Fly   414 DDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAM 478
            |||||||||||:||:||:||||||||||:||||||||:|||::|:||||||.||.|||:|||:|:
pombe   412 DDVDLEQIAAETHGYVGSDLASLCSEAAMQQIREKMDMIDLDEDEIDAEVLDSLGVTMDNFRFAL 476

  Fly   479 TKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPG 543
            ..|:|||||||||||||..|.||||||.||:||:|.||.||.:.:|||:||:.||:||||:||||
pombe   477 GSSNPSALRETVVEVPNVRWEDIGGLEEVKRELRETVQMPVMYAEKFLRFGVTPSKGVLFFGPPG 541

  Fly   544 CGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKAR 608
            .|||||||||||||.||||||||||||:|||||||:||||||||||:|||||:|.||||||||||
pombe   542 TGKTLLAKAIANECSANFISVKGPELLSMWFGESESNVRDIFDKARAAAPCVVFLDELDSIAKAR 606

  Fly   609 GGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDK 673
            |.:.||:|| .|||:||:||||||:.:|||||:||||||||.||||::||||||||||:||||::
pombe   607 GASAGDSGG-GDRVVNQLLTEMDGVNSKKNVFVIGATNRPDQIDPALMRPGRLDQLIYVPLPDEE 670

  Fly   674 SREAILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAEN 738
            :|.:||:..||.:|:|::|||..:||.|.|||||||..:.|||.||||:.:||.:|:||.|..|.
pombe   671 ARFSILQTQLRHTPVAEDVDLRAVAKATHGFSGADLEFVVQRAVKLAIKDSIEEDIKRENETGEA 735

  Fly   739 QNSAMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFGQNFRFPGQTGN 803
            ....:.||||..|.::...|.|||||.|||||||.::|:||.:|..|..|||. ..|:|.....|
pombe   736 PADDVVMDEDASVSQVQRHHVEEAMKMARRSVSDAEVRRYEAYAHQLLTSRGL-TGFQFDSADSN 799

  Fly   804 TSGSGNNLPVNSPGDNGDDDLYS 826
            |:|.       |.|::|.||||:
pombe   800 TNGP-------SFGNDGADDLYA 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	526/739 (71%)
		CDC48_N	47..129	CDD:280513	48/81 (59%)
		CDC48_2	153..213	CDD:215011	33/59 (56%)
		AAA	263..392	CDD:278434	116/128 (91%)
		AAA	536..669	CDD:278434	108/132 (82%)
		Vps4_C	<741..783	CDD:286426	21/41 (51%)
cdc48	NP_593287.2	CDC48_N	45..127	CDD:280513	48/81 (59%)
		CDC48	58..782	CDD:273521	517/724 (71%)
		CDC48_2	151..209	CDD:215011	31/57 (54%)
		AAA	261..390	CDD:278434	116/128 (91%)
		AAA	534..666	CDD:278434	108/132 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	237	1.000	Domainoid score	I475
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5168
Inparanoid	1	1.050	1104	1.000	Inparanoid score	I24
OMA	1	1.010	-	-		QHG60945
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		oto101705
orthoMCL	1	0.900	-	-		OOG6_100525
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R182
SonicParanoid	1	1.000	-	-		X1760
TreeFam	1	0.960	-	-
	14	13.860