DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and Iqca1l

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_808344.3	Gene:	Iqca1l / 231045	MGIID:	3045319	Length:	825	Species:	Mus musculus

Alignment Length:	858	Identity:	170/858 - (19%)
Similarity:	313/858 - (36%)	Gaps:	255/858 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MRGYHSEQDEKMKPKDSFDKR-------EDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKM 68
            :|.::...|:.::|:    ||       :.:|..:|:.||...|:.:.|....|..:..|.....
Mouse    54 LRRFNLAYDQMVQPQ----KRRLLRRLLDGVAGRVLELKDELVRVDLCETHCLDRVLQDLKLTPA 114

  Fly    69 D-------ELQLFRGDTVILKGKRRKETVCIVLS--DDTCPDEKIR-MNRVVRNNLCVHLSDVVS 123
            |       ..||.:...|    |.|::.:..:|:  :.....|.:| ::|.         :.::.
Mouse   115 DLEVPIPKYFQLEQSSAV----KARQQMLADILNRLEPLVSQENLRGLSRT---------AALIL 166

  Fly   124 VQSCPDVKYGKR----VRILPIDESTEG-----------------VTGNLFEIYLKPYFLEAYRP 167
            |||....:.|:.    :|.:..:|..:.                 |...:::.||:...:|..|.
Mouse   167 VQSAERARQGRLRATFMREIRKEEERDRRIWENGQQKFSRDQGAIVIQKVWKGYLQRKRIEQDRR 231

  Fly   168 IHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKR----EEEEESLNAVG--YD 226
            :.|             ||..:|..|.....:......|. |:..:|    |:|||...|:|  |:
Mouse   232 VEM-------------EFIGMLPSPNQTARLNTLNQAFL-GEESRRMRQVEKEEEFQEAIGKTYE 282

  Fly   227 DI----GGCRKQLAQIKEMVE--------LPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARA 279
            .:    |...|:  ::|:.:.        |..|.|.               |....:|.:.:
Mouse   283 SLTETEGPDMKE--RMKDQIRQWFIECHALTGRFPD---------------YPDEASGGSYL--- 327

  Fly   280 VANETGAFFFLINGPE-IMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVE 343
                    .|....|| :...|..:::.:.:|..|:.|||.         :....|::|...:|:
Mouse   328 --------IFADKTPEQVRLDLEAQAQESRKKDQEKKEKNK---------EKEKEKKEKKKKKVK 375

  Fly   344 RRIVSQLLTLMDGMKKSSHLIVMAA---------TNRPNSIDPA-------LRRFGRFDREIDIG 392
            ...|.:...:|..:..|..:.|:.|         .:|.::..|:       ||...|...|::|.
Mouse   376 EEKVKKEPEVMFRVLPSKSIPVINAGHEEYTSVWKSRYDNKHPSQNFDSETLREEKRKQVEMEIR 440

  Fly   393 IP-DATGRLEVLRIHTKNMKLHDDVDLEQI-AAESHGHVGA----------DLA------SLCSE 439
            :. |     |::|...||::|  .||.|:. ..:|....|.          ||.      ||..|
Mouse   441 VQVD-----ELMRQELKNLRL--AVDREETRPLKSPKKKGGKKSGKKKKEKDLTPDRSVDSLFEE 498

  Fly   440 AALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGL 504
            ..:..:.:|..|:.|.|...|...|.| .:|:.|                  ::|..:..||
Mouse   499 LVIIGLIKKSALVTLSDYIGDCLYLGS-TLTLAN------------------KMPMPSLFDI--- 541

  Fly   505 ESVKKELQELVQYPVEHPDKFLKFG------MQP-SRGVLFYGPPGCGKTLLAKAIANECQANFI 562
                  .|.:..|.|      |:.|      |.| .|.:|..||.|.||.:|.:|:..|..||..
Mouse   542 ------RQNMALYGV------LRLGSHDIHTMAPLVRSILLVGPSGMGKKMLVQAVCTETGANLF 594

  Fly   563 SVKGPELLTMWFGESEAN--VRDIFDKARSAAPCVLFFDELD-----SIAKARGGNVGDAGGAAD 620
            .:....|:..:.|::.|.  |..:|..||...|.|::....:     .:.|            .:
Mouse   595 DLSPDNLMGKYPGKNGAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPK------------EE 647

  Fly   621 RVINQILTEMDGMGAKK------NVFIIGATNRPDIID-PAILRPGRLDQLIYIPLPDDKSREAI 678
            |.::....:.|.|.|.|      .|.:||.|.||.:.: ..:.|  ..:::::||.||..||..:
Mouse   648 RTMDPKRIKKDLMRATKQLSPGDRVMLIGTTERPQLAEMKGLCR--FYERILFIPRPDYASRYVL 710

  Fly   679 LKANL----RKSPLAKEVDLTYIAKVTQGFSGADLTEICQ------RACKLAIRQAIEAE----- 728
            .|..:    |...|...:|::.:|:|:.|::.:.:.:..|      |..:|..:..:.:|
Mouse   711 WKRMIESQGRGVQLTSSLDVSALARVSDGYTPSHILQSIQSVLTERRLLQLIKKPLVASEFVGHL 775

  Fly   729 -----IRREKERA 736
                 :.||:|.:
Mouse   776 ARLDPVYREEEES 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	161/815 (20%)
		CDC48_N	47..129	CDD:280513	17/91 (19%)
		CDC48_2	153..213	CDD:215011	11/59 (19%)
		AAA	263..392	CDD:278434	25/145 (17%)
		AAA	536..669	CDD:278434	34/146 (23%)
		Vps4_C	<741..783	CDD:286426
Iqca1l	NP_808344.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..378		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..487		5/27 (19%)
		SpoVK	<566..745	CDD:223540	47/192 (24%)
		AAA	568..701	CDD:278434	34/146 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900