DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and mac-1

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_496814.1	Gene:	mac-1 / 174974	WormBaseID:	WBGene00003119	Length:	813	Species:	Caenorhabditis elegans

Alignment Length:	830	Identity:	269/830 - (32%)
Similarity:	422/830 - (50%)	Gaps:	171/830 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EQDEKMKPKDSFDKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFRGDTVIL 81
            |.||||:.|::.|..:::  .|:|..:...|......:.......:..:
Worm    72 ENDEKMEEKEAMDDVQEI--PIVKALETRKRKAPAAGRKSTGQAAAAKE---------------- 118

  Fly    82 KGKRRKETVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTE 146
                      :|||||: .||     |..|                   :..|::..|..:.:.:
Worm   119 ----------VVLSDDS-EDE-----RAAR-------------------QLEKQIESLKTNRANK 148

  Fly   147 GVTGNLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETV---IFCDG 208
            .|. ||:.....|     ..|:....|   :|..:|           |....||..:   :....
Worm   149 TVL-NLYTKKSAP-----STPVSTPKN---QATKKP-----------PGASAAPPALPRGLGAVS 193

  Fly   209 DPIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGK 273
            |.|...|..     |.::.|||..:|..::..:. :.|:.|..|..:||.||||.:::||||.||
Worm   194 DTISPRESH-----VKFEHIGGADRQFLEVCRLA-MHLKRPKTFATLGVDPPRGFIVHGPPGCGK 252

  Fly   274 TLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKT 338
            |:.|:|||.|.......:...|::|.::||:|..:|:.|:.|::|||.|:.:|:||||||:|:..
Worm   253 TMFAQAVAGELAIPMLQLAATELVSGVSGETEEKIRRLFDTAKQNSPCILILDDIDAIAPRRETA 317

  Fly   339 HGEVERRIVSQLLTLMDGM-----------------------------KKSSHLIVMAATNRPNS 374
            ..|:|||:||||.:.:|.:                             ...:.::|:..|:||::
Worm   318 QREMERRVVSQLCSSLDELVLPPREKPLKDQLTFGDDGSVAIIGDSPTAAGAGVLVIGTTSRPDA 382

  Fly   375 IDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSE 439
            :|..|||.|||:.||.:||||.|.|.::|....| :.|..||.|:|||..:.|:|||||.:|..|
Worm   383 VDGGLRRAGRFENEISLGIPDETAREKILEKICK-VNLAGDVTLKQIAKLTPGYVGADLQALIRE 446

  Fly   440 AA----------------------LQQIREKMDLI------DLEDDKIDAEVLASLAVTMENFRY 476
            ||                      ::||:|::|.:      | :|....:|:...|.::.|:|..
Worm   447 AAKVAIDRVFDTIVVKNEGHKNLTVEQIKEELDRVLAWLQGD-DDPSALSELNGGLQISFEDFER 510

  Fly   477 AMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGM--QPSRGVLFY 539
            |::...|:|.||....||:.:|.|||.|..|:|:|:..:.||::..|.|...|:  :| :|:|..
Worm   511 ALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDCRP-QGILLC 574

  Fly   540 GPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSI 604
            |||||||||||||:|||...|||||||||||.|:.||||..||.:|.:||.:.|||:||||:|::
Worm   575 GPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVFQRARDSQPCVIFFDEIDAL 639

  Fly   605 AKARGGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPL 669
            ...|  :.|::.|.| |::||:||||||:..::.||:|||||||||:|.|||||||||:::::..
Worm   640 VPKR--SHGESSGGA-RLVNQLLTEMDGVEGRQKVFLIGATNRPDIVDAAILRPGRLDKILFVDF 701

  Fly   670 PDDKSREAILKANLR---KSPLAKEVDLTYIAKVTQ--GFSGADLTEICQRACKLAIRQAIEAEI 729
            |..:.|..||:.:.:   :..|.:::|...||::.:  ||:||||..:...:..||::..:
Worm   702 PSVEDRVDILRKSTKNGTRPMLGEDIDFHEIAQLPELAGFTGADLAALIHESSLLALQARV---- 762

  Fly   730 RREKERAENQNSAMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYE 779
                           ::.|:.|..:...||.||....|.||::.|.:|||
Worm   763 ---------------LENDESVKGVGMRHFREAASRIRPSVTEADRKKYE 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	260/800 (33%)
		CDC48_N	47..129	CDD:280513	10/81 (12%)
		CDC48_2	153..213	CDD:215011	10/62 (16%)
		AAA	263..392	CDD:278434	54/157 (34%)
		AAA	536..669	CDD:278434	80/132 (61%)
		Vps4_C	<741..783	CDD:286426	13/39 (33%)
mac-1	NP_496814.1	Nucleolin_bd	5..65	CDD:318849
mac-1	NP_496814.1	TIP49	<191..804	CDD:332389	237/638 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820