DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and cdc-48.2

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_495705.1	Gene:	cdc-48.2 / 174309	WormBaseID:	WBGene00008053	Length:	810	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	637/826 - (77%)
Similarity:	722/826 - (87%)	Gaps:	26/826 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MRGYHSEQDEKMKPKDSFDKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFR 75
            |....:::|||.|      |.::|||||||.|.||||||::::.|||||:|.|||||||||.|||
Worm     1 MASVPTQRDEKEK------KNDELATAILKDKKRPNRLIIDQSDNDDNSMVMLSQAKMDELGLFR 59

  Fly    76 GDTVILKGKRRKETVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILP 140
            ||:||||||:|:|||.|||:.|.||::||:||:||||||...|.||||:.|. .::|||||.:||
Worm    60 GDSVILKGKKRRETVSIVLNADNCPNDKIKMNKVVRNNLRSRLGDVVSISSA-QLEYGKRVHVLP 123

  Fly   141 IDESTEGVTGNLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIF 205
            ||::.||:|||||:::|:|||.:||||:|.||.|.|:||||.:|||||.|||.|.|||||:|||.
Worm   124 IDDTIEGLTGNLFDVFLRPYFTDAYRPVHKGDIFTVQAAMRTVEFKVVETDPAPACIVAPDTVIH 188

  Fly   206 CDGDPIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPG 270
            .:|||||||||||:||.|||||:||.||||||||||||||||||.||||||||||||||::||||
Worm   189 YEGDPIKREEEEEALNEVGYDDLGGVRKQLAQIKEMVELPLRHPQLFKAIGVKPPRGILLFGPPG 253

  Fly   271 TGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKR 335
            |||||||||||||||||||||||||||||::|||||||||||.|.|||||||:||||||||||||
Worm   254 TGKTLIARAVANETGAFFFLINGPEIMSKMSGESESNLRKAFAECEKNSPAILFIDEIDAIAPKR 318

  Fly   336 DKTHGEVERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRL 400
            :|.|||||:||||||||||||:|..:|::|:||||||||||.|||||||||||||||||||.|||
Worm   319 EKAHGEVEKRIVSQLLTLMDGLKTRAHVVVIAATNRPNSIDGALRRFGRFDREIDIGIPDAVGRL 383

  Fly   401 EVLRIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLA 465
            |:||||||||||.:||||||:|.|.||.|||||||||||||:|||||||:|||||||.||||||.
Worm   384 EILRIHTKNMKLGEDVDLEQVANECHGFVGADLASLCSEAAIQQIREKMELIDLEDDTIDAEVLN 448

  Fly   466 SLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGM 530
            ||||||||||:||.|||||||||.|||.|||||:|||||::||:|||||||||||||:|:|||||
Worm   449 SLAVTMENFRFAMGKSSPSALREAVVETPNTTWSDIGGLQNVKRELQELVQYPVEHPEKYLKFGM 513

  Fly   531 QPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCV 595
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||:|||||:|||||
Worm   514 QPSRGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCV 578

  Fly   596 LFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGR 660
            |||||||||||||||:||||||||||||||:|||||||.||||||||||||||||||||:|||||
Worm   579 LFFDELDSIAKARGGSVGDAGGAADRVINQVLTEMDGMNAKKNVFIIGATNRPDIIDPAVLRPGR 643

  Fly   661 LDQLIYIPLPDDKSREAILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAI 725
            |||||||||||:.||..|.||:|||:||:.::||.::||.|.||||||||||||||||||||::|
Worm   644 LDQLIYIPLPDEASRLQIFKASLRKTPLSADLDLNFLAKNTVGFSGADLTEICQRACKLAIRESI 708

  Fly   726 EAEIRREKERAENQNSAMDMDED---DPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQ 787
            |.|||:||||.:......::.||   |||||||.||||||||||||||:||||||||||||||||
Worm   709 EREIRQEKERQDRSARGEELMEDELADPVPEITRAHFEEAMKFARRSVTDNDIRKYEMFAQTLQQ 773

  Fly   788 SRGFGQNFRFPGQ-------TGNTSGSGNNLPVNSPGDNGDDDLYS 826
            |||||.||:|||:       .|...|||.         |.|||||:
Worm   774 SRGFGNNFKFPGEAPSAGQPVGGNGGSGG---------NDDDDLYN 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	598/742 (81%)
		CDC48_N	47..129	CDD:280513	55/81 (68%)
		CDC48_2	153..213	CDD:215011	39/59 (66%)
		AAA	263..392	CDD:278434	110/128 (86%)
		AAA	536..669	CDD:278434	125/132 (95%)
		Vps4_C	<741..783	CDD:286426	33/44 (75%)
cdc-48.2	NP_495705.1	CDC48_N	31..112	CDD:280513	55/81 (68%)
		CDC48	44..773	CDD:273521	590/729 (81%)
		CDC48_2	136..196	CDD:215011	39/59 (66%)
		AAA	246..375	CDD:278434	110/128 (86%)
		AAA	519..652	CDD:278434	125/132 (95%)
		Vps4_C	<725..769	CDD:286426	33/43 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158378
Domainoid	1	1.000	265	1.000	Domainoid score	I1009
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5168
Inparanoid	1	1.050	1264	1.000	Inparanoid score	I79
Isobase	1	0.950	-	0	Normalized mean entropy	S74
OMA	1	1.010	-	-		QHG60945
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		otm14364
orthoMCL	1	0.900	-	-		OOG6_100525
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R182
SonicParanoid	1	1.000	-	-		X1760
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790