DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TER94 and cdc-48.3

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_492211.1	Gene:	cdc-48.3 / 172586	WormBaseID:	WBGene00010562	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	211/752 - (28%)
Similarity:	349/752 - (46%)	Gaps:	178/752 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 VSLSQAKMDELQLFRGDTVILKGKRRKETVCIVLSDDT-------CPD-----EKIRMNRVVRNN 113
            :.::|..|:.|           |...::.|.|:.|.|:       |.:     ..|..:|:.|..
Worm    76 ILINQQTMESL-----------GLLARQPVRIIHSSDSFIGIVWPCKEVALLKVSIISSRIARER 129

  Fly   114 LCVHLSDVVSVQSCPDVKYGKRVRI-----LPIDESTEGVTGNLFEIYLKPYFLEAYRPI---HM 170
            :       ::::||..|:..|.:.:     |.::.:..|    ..|.||...:|:....:   ::
Worm   130 M-------ITLESCGRVEKLKSLSVTVKTSLTLNPALSG----FLEAYLSHSYLQYNSSVDLKYL 183

  Fly   171 GDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVGY---------- 225
            |.|             |.:|..||  |.:..:.:..|.|  |:...:....||||
Worm   184 GQN-------------VTVTPEEP--IESKMSAMGIDDD--KKRNSKVVSTAVGYKIQILNASAE 231

  Fly   226 --------------DDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLI 276
                          .:||||......:::.|..|:|..        :.|..:|::|.||:||||:
Worm   232 GSTSDVLQTLPTDLSNIGGCFTAKQVLEDYVISPVRQK--------ESPCSVLIWGLPGSGKTLL 288

  Fly   277 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGE 341
            .:.||.........|...|.:.:|.|.:..|:            .|:.::|:            |
Worm   289 LKEVALVLSGSTTYIGSCEELMELNGVTTGNI------------VIVDVNEL------------E 329

  Fly   342 VERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVL--- 403
            .|....::.|:.:.|.:|.   .|:.......::|...|  .||..|.:|.:|....||::|
Worm   330 KENTKANRALSFLLGDEKK---CVILCVRSSETLDIGFR--VRFPIEAEITVPTQDERLDILSKI 389

  Fly   404 -RIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASL 467
             .|:...::||.||     |..:||..|.||.||...|...:.|..::.::      ||.
Worm   390 GNIYNFPLELHLDV-----ARHTHGFTGGDLCSLLKAAKFARGRTHLERVN------DAR----- 438

  Fly   468 AVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQP 532
                       .:..|:.:|:.::||||.:|.||||.|.:|.|:|:.|.:|.:||:.|.:||:.|
Worm   439 -----------KRIRPTGIRQFILEVPNVSWNDIGGNEELKLEIQQAVIWPQKHPEAFERFGIDP 492

  Fly   533 SRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLF 597
            ..|:|.||||||.|||:|:|:|:|.:.||::||||||.:.|.|:||..:||:|.:||..||.::|
Worm   493 PAGILLYGPPGCSKTLIARALASEAKMNFLAVKGPELFSKWVGDSEKAIRDLFSRARQVAPTIVF 557

  Fly   598 FDELDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLD 662
            |||:|::..:||..  .:.|.:|||:.|:|||:||:.....|.::.||||||.:|.|:|||||||
Worm   558 FDEIDAVGSSRGSE--KSSGVSDRVLAQLLTELDGLEKSSRVILLAATNRPDQLDSALLRPGRLD 620

  Fly   663 QLIYIPLPDDKSREAILKANLRKSPLAKEV-DLTYIAKVTQGFSGADLTEICQRACKLAIRQAIE 726
            :.||:.||.:.:|.|||:...:|......| .:..:.:.|.|:|||:|..:|:.|...|:|::|:
Worm   621 RAIYVGLPCEVTRRAILEMRTKKMKFDDTVRTIDKLVEKTSGYSGAELVAVCRTAAMFAMRESID 685

  Fly   727 AEIRREKERAENQNSAMDMDEDDPVPEITSAHFEEAM 763
            |.|                        :...|||:|:
Worm   686 ATI------------------------VQWTHFEQAL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	211/752 (28%)
		CDC48_N	47..129	CDD:280513	14/79 (18%)
		CDC48_2	153..213	CDD:215011	13/62 (21%)
		AAA	263..392	CDD:278434	28/128 (22%)
		AAA	536..669	CDD:278434	68/132 (52%)
		Vps4_C	<741..783	CDD:286426	4/23 (17%)
cdc-48.3	NP_492211.1	TIP49	<247..720	CDD:332389	175/542 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820