DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and SPATA5

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_016863314.1	Gene:	SPATA5 / 166378	HGNCID:	18119	Length:	917	Species:	Homo sapiens

Alignment Length:	830	Identity:	314/830 - (37%)
Similarity:	465/830 - (56%)	Gaps:	125/830 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EQDEKMKPKDSFDKREDLATAILKRKD----------------RPNRLIVEEAQNDDNSVVSLSQ 65
            |.|..:..||.....|:|...||::.|                ||.:|.|...:..|..::...|
Human   143 EMDVALSDKDMEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRPYKLQVLRVKGADGMILGGPQ 207

  Fly    66 AKMD---ELQLFRGDTVILKGKRRKETVCIVLS---------DDTCPDEKIRMNRVVRNNLCVHL 118
            :..|   :...|...::        ||..:.||         |...|..:....:.:.:.:....
Human   208 SDSDTDAQRMAFEQSSM--------ETSSLELSLQLSQLDLEDTQIPTSRSTPYKPIDDRITNKA 264

  Fly   119 SDV-VSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRP 182
            ||| :.|...|....|     |.::|    |||      ||..|..|..     .|..:....|.
Human   265 SDVLLDVTQSPGDGSG-----LMLEE----VTG------LKCNFESARE-----GNEQLTEEERL 309

  Fly   183 IEFKV---VLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVEL 244
            ::|.:   ..||.. |.|.:...|.|.:.|  |..:|:::...|.||.|||...||..|:|::||
Human   310 LKFSIGAKCNTDTF-YFISSTTRVNFTEID--KNSKEQDNQFKVTYDMIGGLSSQLKAIREIIEL 371

  Fly   245 PLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLR 309
            ||:.|.|||:.|:..|||:|:|||||||||:||||||||.||:..:||||||:||..||:|:.||
Human   372 PLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLR 436

  Fly   310 KAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLMDGM---KKSSHLIVMAATNR 371
            :.|.||....|:||||||:||:.|||:....|||:|:|:.|||||||:   .....::|:.||||
Human   437 QIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNR 501

  Fly   372 PNSIDPALRRFGRFDREIDIGIPDATGRLEVL-RIHTKNMKLHDDVDLEQIAAESHGHVGADLAS 435
            |:::|.||||.||||:||:||:|:|..||::| ::..:...|..:.:|.|:|..:||:|||||..
Human   502 PHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKV 566

  Fly   436 LCSEA---------------------------ALQQIREKMDLIDLEDDKIDAEVLASLAVTMEN 473
            ||:||                           ||::|.:|      :.:..|.:|...:.:|:::
Human   567 LCNEAAGTRILKAHMYVSAFATGLTQTPQGLCALRRILKK------QPNLPDVKVAGLVKITLKD 625

  Fly   474 FRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLF 538
            |..||....|||:||..::|||.:|:|||||||:|.:|::.|::|::||:.|::.|:||.:|||.
Human   626 FLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLL 690

  Fly   539 YGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDS 603
            ||||||.||::|||:|||...||:::|||||:..:.||||..||:.|.|||:.||.::||||||:
Human   691 YGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDA 755

  Fly   604 IAKARGGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIP 668
            :|..||.::| ||..||||:.|:||||||:...|:|.|:.||||||.||.|::||||:|::||:|
Human   756 LAVERGSSLG-AGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVP 819

  Fly   669 LPDDKSREAILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREK 733
            |||..:|..|.|......|::.||||..:...|..:|||::..:|:.|..||:.:.|:|.:
Human   820 LPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANL---- 880

  Fly   734 ERAENQNSAMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQ 783
                                |...||.:|:......:.::..|.||.:.:
Human   881 --------------------IMKRHFTQALSTVTPRIPESLRRFYEDYQE 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	303/784 (39%)
		CDC48_N	47..129	CDD:280513	16/94 (17%)
		CDC48_2	153..213	CDD:215011	14/62 (23%)
		AAA	263..392	CDD:278434	77/131 (59%)
		AAA	536..669	CDD:278434	77/132 (58%)
		Vps4_C	<741..783	CDD:286426	7/41 (17%)
SPATA5	XP_016863314.1	CDC48_N	65..133	CDD:389870
SPATA5	XP_016863314.1	CDC48	<323..913	CDD:273521	271/622 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820