DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and Pex6

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_476466.1	Gene:	Pex6 / 117265	RGDID:	621637	Length:	978	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	233/756 - (30%)
Similarity:	378/756 - (50%)	Gaps:	127/756 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 TVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGN-- 151
            |:...|..|.....::|:.|.:.::...  .|..|....|...:.:.:.|..:.....||.|.
  Rat   276 TLAFNLGCDPLEVGELRIQRYLEDSTAA--EDKGSCSLLPGPPFARELHIEVLPSPHCGVNGKYD 338

  Fly   152 --LFEIYLKPYFLEAYRPIHMGDNFIVRAA---------------MRPIEFKVVLTDPEPYCIVA 199
              |::.:..|      |.:..||...|..|               .|.:.|||..|..|     |
  Rat   339 HVLYQHFHTP------RVVQEGDVLCVSTAGQVEILEGSLERLPRWREVFFKVKKTVGE-----A 392

  Fly   200 PE------------TVIFCDGD--------PIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVEL 244
            |:            |.::..|.        |..|....:||:..|.:         |.:.|:..:
  Rat   393 PDGPASAFLADTTHTSLYLAGTTLSRVPPLPSGRSPPWDSLSPPGLE---------ALVNELCAV 448

  Fly   245 PLRHPSLFKAIGVKP---PRG--------ILMYGPPGTGKTLIARAVANETGAFFFLINGPEIMS 298
                        :||   |.|        :|:.||||:|||....|..:..|  ..|:..|  .|
  Rat   449 ------------LKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLG--LHLLKVP--CS 497

  Fly   299 KLAGES----ESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLM---DG 356
            .|..:|    |:.|:..|..|.:..|.::.:..:|.:...||.. || :.|:|:.|..|:   |.
  Rat   498 SLCADSSRTVETKLQTTFSRARRCRPVVLLLTALDLLGRDRDGL-GE-DARVVATLRHLLLDEDP 560

  Fly   357 MKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDVDLEQI 421
            :.:...|:|:|.|:|...:...:|.  .|..|:::.:...:.||.||:..|.::.|..:|:|.|:
  Rat   561 LSRCPPLMVVATTSRVQDLPTDVRT--AFPHELEVPVLSESQRLSVLQALTAHLPLGQEVNLSQL 623

  Fly   422 AAESHGHVGADLASL---CSEAALQQIREKMDLIDLEDDKIDAEVLAS-LAVTMENFRYAMTKSS 482
            |....|.|..||.:|   .|.||..:|:.....:..||   :.|:.|: ..:..|:|..|:.:..
  Rat   624 ARRCAGFVVGDLYALLTHASRAACTRIKAAGLAMSEED---EGELCAAGFPLLAEDFGQALDQLQ 685

  Fly   483 PSALRETV--VEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCG 545
             :|..:.|  .::|:.:|.|:|||:.||||:.|.:|.|:|||: .|..|::.| |:|.:||||.|
  Rat   686 -TAHSQAVGAPKIPSVSWHDVGGLQDVKKEILETIQLPLEHPE-LLSLGLRRS-GLLLHGPPGTG 747

  Fly   546 KTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGG 610
            |||||||:|.||...|:|||||||:.|:.|:||.|||::|.:||:||||::|||||||:|.:||.
  Rat   748 KTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGR 812

  Fly   611 NVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDK-S 674
            : ||:||..|||::|:|.|:||:.:.::||:||||||||::|||:|||||.|:|:::...:|: |
  Rat   813 S-GDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGASEDRAS 876

  Fly   675 REAILKANLRKSPLAKEVDLTYIAK-VTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAEN 738
            :..:|.|..||..|...|.|..:.. .....:||||..:|..|...|:::    .:|..:|..|.
  Rat   877 QLRVLSAITRKFKLEASVSLMNVLDCCPPQLTGADLYSLCSDAMMTALKR----RVRDLEEGLEP 937

  Fly   739 QNSAMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYE 779
            ::||:.:..:|.:         :|....:.|||:.::.:|:
  Rat   938 RSSALLLTMEDLL---------QAAARLQPSVSEQELLRYK 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	233/756 (31%)
		CDC48_N	47..129	CDD:280513	7/39 (18%)
		CDC48_2	153..213	CDD:215011	17/94 (18%)
		AAA	263..392	CDD:278434	38/135 (28%)
		AAA	536..669	CDD:278434	80/132 (61%)
		Vps4_C	<741..783	CDD:286426	8/39 (21%)
Pex6	NP_476466.1	SpoVK	463..965	CDD:223540	192/529 (36%)
		AAA	466..595	CDD:278434	38/136 (28%)
		AAA	741..869	CDD:278434	79/128 (62%)
		Vps4_C	923..975	CDD:286426	12/60 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810