DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TER94 and nvl

DIOPT Version :9

Sequence 1:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001096509.1	Gene:	nvl / 100125138	XenbaseID:	XB-GENE-958000	Length:	852	Species:	Xenopus tropicalis

Alignment Length:	621	Identity:	260/621 - (41%)
Similarity:	373/621 - (60%)	Gaps:	76/621 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 NAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETG 285
            ::|.::||||....|.::.:|: :.:|||.:::.:||.||||.|::||||.||||:|:|:|.|..
Frog   254 SSVRFEDIGGNEDTLKEVCKMM-IHMRHPEVYQHLGVVPPRGFLLHGPPGCGKTLLAQAIAGELD 317

  Fly   286 AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQL 350
            .....:...|::|.::||||..||:.||:|..::|.|:||||||||.|||:....::|||||:||
Frog   318 LPMLKVAATEMVSGVSGESEQKLRELFEQAVSSAPCILFIDEIDAITPKREVASKDMERRIVAQL 382

  Fly   351 LTLMDGMKK---SSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKL 412
            ||.||.:..   ::.::|:.|||||:|:||||||.|||||||.:||||...|..:|:...:.:||
Frog   383 LTCMDDLNSLAVTAQVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEGARKRILQTLCRKLKL 447

  Fly   413 HDDVDLEQIAAESHGHVGADLASLCSEAA-------LQQIREKM--------------DLIDLED 456
            .:..|..::|..:.|:|||||.:||.|||       |.|::|:.              :.:.|:.
Frog   448 PEPFDYCRLAHLTPGYVGADLMALCREAAMCAVNRVLIQLKEQQATPEAAVEETAPQPEALALQA 512

  Fly   457 DK----------------------IDAEVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWT 499
            :|                      :..|.|.||.:.|::|..|:....|||.||....||:.||.
Frog   513 EKQTTGPAQSELHRLLALLQEHTPLPEEELQSLCIEMDDFLGALPSVQPSAKREGFATVPDVTWA 577

  Fly   500 DIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISV 564
            |||.||.:::||...:..||::|::|...|:....|||..|||||||||||||:|||...|||||
Frog   578 DIGALEEIREELTMAILAPVKNPEQFKALGLMAPAGVLLAGPPGCGKTLLAKAVANESGLNFISV 642

  Fly   565 KGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTE 629
            ||||||.|:.||||..||.:|.:|.:::|||:||||:|::...|.|.   ..||:.||:||:|||
Frog   643 KGPELLNMYVGESERAVRQVFQRASNSSPCVIFFDEIDALCPRRSGY---ESGASVRVVNQLLTE 704

  Fly   630 MDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANLR---KSPLAKE 691
            |||:.:::.|||:.|||||||||||||||||||:.:|:.||....|.||||...:   :.||..:
Frog   705 MDGLESRRQVFIMAATNRPDIIDPAILRPGRLDKTLYVGLPPPADRLAILKTITKDGTRPPLEAD 769

  Fly   692 VDLTYIA--KVTQGFSGADLTEICQRACKLAIRQ---AIEAEIRREKERAENQNSAMDMDEDDPV 751
            |||..||  :....|:||||:.:.:.|...|:||   .:|....|.:.:
Frog   770 VDLEAIAGDECCDCFTGADLSALVREASVSALRQEMLGLEPPTNRGQIK---------------- 818

  Fly   752 PEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQ 787
              ::..|||||....:.|||..|...||...|:|.:
Frog   819 --VSRRHFEEAFSKVKPSVSKKDQLMYENLRQSLSR 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	260/619 (42%)
		CDC48_N	47..129	CDD:280513
		CDC48_2	153..213	CDD:215011
		AAA	263..392	CDD:278434	68/131 (52%)
		AAA	536..669	CDD:278434	83/132 (63%)
		Vps4_C	<741..783	CDD:286426	11/41 (27%)
nvl	NP_001096509.1	Nucleolin_bd	2..72	CDD:293330
		SpoVK	278..848	CDD:223540	251/590 (43%)
		AAA	296..427	CDD:278434	68/130 (52%)
		P-loop_NTPase	594..>630	CDD:304359	19/35 (54%)
		AAA	614..744	CDD:278434	83/132 (63%)
		Vps4_C	<808..>839	CDD:286426	10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010