Protein Alignment eve and ALX4

DIOPT Version :10

• Sequence 1: NP_523670.2
• Gene: eve / 36039
• FlyBaseID: FBgn0000606
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_068745.2
• Gene: ALX4 / 60529
• HGNCID: 450
• Length: 411
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 82/302 - (27%)
• Similarity: 114/302 - (37%)
• Gaps: 93/302 - (30%)

  Fly    36 GKPQTPPPS-----PNECLSSPDNSLNGSR---GSEIP-----ADP-----SVRRYRTAFTRDQL 82
            |:|:.||.|     .:..||..:..:.|.:   .|::|     ||.     ..||.||.||..||
Human   162 GEPELPPDSDTVGMDSSYLSVKEAGVKGPQDRASSDLPSPLEKADSESNKGKKRRNRTTFTSYQL 226

  Fly    83 GRLEKEFYKENYVSRPRRCELAAQLNLPESTIKVWFQNRRMK-DKRQRIA----VAWPYAAVYSD 142
            ..|||.|.|.:|.....|.:||.:.:|.|:.::|||||||.| .||:|..    |...::..|..
Human   227 EELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYEL 291

  Fly   143 PAFAASILQAAANSVGMPYPPYAPAAAAAAAAAAAVATNPMMATGMPPMGMPQMPTMQMPGHSGH 207
            |     :|..|.|        ||                                .:|.|...|:
Human   292 P-----LLTRAEN--------YA--------------------------------QIQNPSWLGN 311

  Fly   208 AGHPSPYGQYRYTPYHIPA--RPAPPHPA--GPHMHHPHMMGSSATGSSYSAGAAGLLG------ 262
            .|..||          :||  .|..|.||  .||.|.|....||.|.....:||...:|
Human   312 NGAASP----------VPACVVPCDPVPACMSPHAHPPGSGASSVTDFLSVSGAGSHVGQTHMGS 366

  Fly   263 ALPSATCYTGLG----VGVPKTQTPPL-DLQSSSSPHSSTLS 299
            ...:|:...||.    .|.|..:|..: .|:..:..||:.:|
Human   367 LFGAASLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAIS 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eve	NP_523670.2	Homeodomain	71..127	CDD:459649	27/56 (48%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..145
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..219		7/34 (21%)
		Homeodomain	215..271	CDD:459649	27/55 (49%)
		OAR	387..405	CDD:461067	3/17 (18%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	391..404		1/12 (8%)