DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eve and EVX2

DIOPT Version :9

Sequence 1:	NP_523670.2	Gene:	eve / 36039	FlyBaseID:	FBgn0000606	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001073927.1	Gene:	EVX2 / 344191	HGNCID:	3507	Length:	476	Species:	Homo sapiens

Alignment Length:	233	Identity:	105/233 - (45%)
Similarity:	135/233 - (57%)	Gaps:	49/233 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GSEIPADPSVRRYRTAFTRDQLGRLEKEFYKENYVSRPRRCELAAQLNLPESTIKVWFQNRRMKD 125
            ||...|| .||||||||||:|:.|||||||:||||||||||||||.|||||:|||||||||||||
Human   180 GSGSGAD-QVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKD 243

  Fly   126 KRQRIAVAWPYAAVYSDPAFAASILQAAANSVGMPYP----------PY----APAAAAAAAAAA 176
            ||||:|::||:.|   ||:|...::..||.:..:|||          |:    |.||||||:.||
Human   244 KRQRLAMSWPHPA---DPSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAAASGAA 305

  Fly   177 AVATNPMMATGMPPMGMPQMPTMQMPGHSGHAGHPSPYGQ------YRYTP-YHIPARPAPPHPA 234
            |.|::| .||.:.|     :.|.:...|        ||.:      :|:.. |..||..|..:.|
Human   306 AAASSP-FATSIRP-----LDTFRALSH--------PYSRPELLCSFRHPGLYQAPAAAAGLNSA 356

  Fly   235 GPHMHHPHMMGSSATGSSYSAGAAGLLGALP---SATC 269
            .       ...::|..::.:|.:|...||.|   ||.|
Human   357 A-------SAAAAAAAAAAAASSAAAAGAPPSGGSAPC 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eve	NP_523670.2	Homeobox	74..126	CDD:278475	45/51 (88%)
EVX2	NP_001073927.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..185		2/4 (50%)
		Homeobox	192..244	CDD:278475	45/51 (88%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6253
eggNOG	1	0.900	-	-		E1_KOG0844
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4277
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002730
OrthoInspector	1	1.000	-	-		otm40654
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46294
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2896
SonicParanoid	1	1.000	-	-		X2525
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	10.040