DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eve and EVX1

DIOPT Version :9

Sequence 1:	NP_523670.2	Gene:	eve / 36039	FlyBaseID:	FBgn0000606	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001980.1	Gene:	EVX1 / 2128	HGNCID:	3506	Length:	407	Species:	Homo sapiens

Alignment Length:	306	Identity:	112/306 - (36%)
Similarity:	147/306 - (48%)	Gaps:	61/306 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TYNMESHHAHHDASPVDQKPLVVDLLATQYGKPQTPPPSPNECLSSPDNSLNGSRGS-EIPADPS 69
            |.|.|..|:....|..        |:.:..|..:||.       |:..:...||:|: ...|...
Human   133 TGNAEYQHSKGSGSEA--------LVGSPNGGSETPK-------SNGGSGGGGSQGTLACSASDQ 182

  Fly    70 VRRYRTAFTRDQLGRLEKEFYKENYVSRPRRCELAAQLNLPESTIKVWFQNRRMKDKRQRIAVAW 134
            :|||||||||:|:.|||||||:||||||||||||||.|||||:|||||||||||||||||:|:.|
Human   183 MRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTW 247

  Fly   135 PYAAVYSDPAFAASILQAAANSVGMPYP-------PYAPAAAAAAAAAAAVATNPMMATGMPPMG 192
            |:.|   ||||...::..||.:.|:|||       ||.......||:||:.|.:|...:..|
Human   248 PHPA---DPAFYTYMMSHAAAAGGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRP--- 306

  Fly   193 MPQMPTMQMPGHSGHAGHPSPYGQYRYTPYHIPARPAPPHPAGPHMHHPHMMGSSATGSSYSAGA 257
               :.|.::      ...|.|..:......|.|..|.|.|                 |...|||
Human   307 ---LDTFRV------LSQPYPRPELLCAFRHPPLYPGPAH-----------------GLGASAG- 344

  Fly   258 AGLLGALPSATCYTGLGVGVPKTQTPPLDLQSSSSPHS-STLSLSP 302
                |......|::|...|:........|...:|:..| |.|:.:|
Human   345 ----GPCSCLACHSGPANGLAPRAAAASDFTCASTSRSDSFLTFAP 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eve	NP_523670.2	Homeobox	74..126	CDD:278475	45/51 (88%)
EVX1	NP_001980.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..179		11/56 (20%)
		HOX	183..239	CDD:197696	48/55 (87%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6253
eggNOG	1	0.900	-	-		E1_KOG0844
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4277
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002730
OrthoInspector	1	1.000	-	-		otm40654
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46294
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2525
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	9.010